Fermentation, Cell Culture, and Recovery

  • Process feasibility analysis and protein expression
  • Fermentation and cell culture, recovery, and process optimization
  • New technology development through collaborations with other NCI investigators, academia and industry
  • Process engineering and scale-up
Fermentation, Cell Culture, and Recovery Fermentation, Cell Culture, and Recovery

Purification Development

  • Develop robust, validated virus removal/inactivation steps for a large number of humanized, chimeric and murine antibodies and fusion proteins.
  • Develop a variety of orthogonal methods to purify proteins and plasmids by charge, size and hydrophobicity.
  • Develop purification processes for herpes virus, poliovirus, and adenovirus platforms and transfer to CGMP manufacturing for production of gene therapy vectors and oncolytic viruses.
Purification Development Purification Development
 

Research and Development

  • 'Dry Lab' Analysis and Feasibility Assessment (including Genetic Stability)
  • Virus Re-Derivation in Qualified Cell Line
  • Optimization of Virus Expansion
  • Virus Seed Production
  • Production of Materials for GLP Toxicology
Virus Research and Development Virus Research and Development