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Interaction between EphrinB1 and CNK1 Found to Play Role in Tumor Progression

Two scientists in the lab. Doctor Cho is on left and Doctor Daar is on right.

Hee Jun Cho, Ph.D., left, with Ira Daar, Ph.D., senior investigator, Laboratory of Cell and Developmental Signaling. 

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By Nancy Parrish, Staff Writer

The family of proteins known as ephrins plays a critical role in a variety of biological processes. In a recent article in the Journal of Biological Chemistry, Hee Jun Cho, Ph.D., and colleagues report on the interaction between proteins CNK1 and ephrinB1 that promotes cell movement. Their findings may have an important implication in developing new therapeutics for reducing metastases in certain cancers.

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Monomeric CH3: A Small, Stable Antibody Domain with Therapeutic Promise

Two men talking by the computer

Tianlei Ying, Ph.D. (facing camera), postdoctoral fellow, and Dimiter Dimitrov, Ph.D., head, Protein Interactions Group, Cancer and Inflammation Program, Center for Cancer Research.

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Antibody domains are emerging as promising biopharmaceuticals because of their relatively small size compared to full-sized antibodies, which are too large to effectively penetrate tumors and bind to sterically restricted therapeutic targets.

In an article published in The Journal of Biological Chemistry, Tianlei Ying, Ph.D., Dimiter Dimitrov, Ph.D., and their colleagues in the Protein Interactions Group, Cancer and Inflammation Program, Center for Cancer Research, reported their design of a novel antibody domain, monomeric CH3 (mCH3).

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Gut Microorganisms Found Necessary for Successful Cancer Therapy

Group photo of four scientists

Giorgio Trinchieri, M.D., seated. Standing, from left: Romina Goldszmid, Ph.D., Amiran Dzutsev, M.D., Ph.D., and C. Andrew Stewart, Ph.D. Not pictured: Noriho Iida, Ph.D.

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By Nancy Parrish, Staff Writer

Humans play host to trillions of microorganisms that help our bodies perform basic functions, like digestion, growth, and fighting disease. In fact, bacterial cells outnumber the human cells in our bodies by 10 to 1.1

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New Approach for Producing and Purifying IL-15 Heterodimers That Have Potent Immune Effect

Elena Chertova and Cristina Bergamaschi

From left: Elena Chertova, Ph.D., head, Retroviral Protein Chemistry Core, AIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research, and Cristina Bergamaschi, Ph.D., staff scientist, Human Retrovirus Pathogenesis Section, Vaccine Branch, Center for Cancer Research

Platinum Highlight IconBy Nancy Parrish, Staff Writer

Cytokines are proteins that play a crucial role in the human immune system by delivering messages that trigger the activation of immune cells to fight off attacks from viruses or other invaders.

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