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LMT Technology Development

LMT is committed to providing NCI scientists with the best genetics and genomics tools available.  To do this, we need to stay at the cutting edge of the rapid technological developments in this field.  At any given time, several experimental services are in development here at LMT; some of these will prove unproductive, while others will move on to become standard services.  We are particularly interested in developing new services that address unmet needs or significantly improve on current offerings by reducing cost, decreasing turn around time, and increasing the amount of useful data provided.

Each technology development project at LMT begins as a proposal requiring NCI stakeholders.  Approved proposals move from initial development to proof-of-principal pilots to investigator driven, ATP-funded collaborations before becoming fully implemented services.  If you are interested in working with us at any stage of current technology development projects or have an idea for a technology development proposal that would benefit your research, please contact Dr. Jennifer Troyer or the scientific lead for the project.

Third generation sequencing platforms

As part of the 2011 genetics and genomics technology development program, ATP participated in early access and pioneer programs for the Ion Torrent and PacBio third generation sequencing platforms (scientific lead: Dr. David Munroe).  These systems have unique features that complement or replace other technologies for specific sequencing needs.  Both are now available as CORE services for limited applications;  We continue to explore additional applications and utilities of this systems and collaborative projects to test unique capabilities of these platforms are welcome.

The LMT also has a new SOLiD 5500 sequencer (scientific lead: Dr. Dan Soppet).  This platform should be available as a CORE service later this year.  The SOLiD 5500 is a flexible second generation massively parallel short read sequencer with potential for exome sequencing, RNAseq expression analysis, ChIPseq, and methylation analysis.

Novel applications for Next Generation Sequencing (NGS)

Anchor Mediated PCR for targeted NGS (scientific lead: Dr. Xiaolin Wu)

Next generation sequencing-based HLA typing (scientific lead: Dr. Jennifer Troyer)

Next generation sequencing-based HPV typing and characterization (scientific lead: Dr. Jennifer Troyer)

Automation of NGS library preparation (scientific lead: Todd Hartley)

Page last updated February 25, 2013 @ 2:42 pm