Affinity Reagents for Analysis of the Human Cancer Proteome
The goal of this project in the Protein Expression Laboratory (PEL) is to establish a system for making peptides that can bind to a specific target. A peptide that binds to a disease related receptor or enzyme could be a drug or diagnostic candidate. Methods orthogonal to phage display are needed to find binders independent of large scaffolds. In our laboratory, we are developing a novel method for screening of specific peptide(s) using highly active cell-free protein synthesis in water-oil emulsion by exploiting a proprietary genotype-phenotype link.