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Affinity Reagents for Analysis of the Human Cancer Proteome

The goal of this project in the Protein Expression Laboratory (PEL) is to establish a system for making peptides that can bind to a specific target.   A peptide that binds to a disease related receptor or enzyme could be a drug or diagnostic candidate.  Methods orthogonal to phage display are needed to find binders independent of large scaffolds.  In our laboratory, we are developing a novel method for screening of specific peptide(s) using highly active cell-free protein synthesis in water-oil emulsion by exploiting a proprietary genotype-phenotype link.

Page last updated March 7, 2012 @ 10:19 am