R24 MONOCLONAL ANTIBODY

Antibody Specificity:   Human GD3

Isotype:   Murine IgG3

Process:   Hybridoma fermentation (Celltech Limited, Lot# 15889JC). Clinical grade/Expired.

Concentration:   2.5 mg IgG/ml

Volume:   4 ml/vial

Buffer:   Isotonic PBS plus human serum albumin (pH 5.9)

Product Testing:
MAP: Cell Line Negative Purity by HPLC: >90%
Mycoplasma: Cell Line Negative Sterility: Pass
Endotoxin: <1 EU/ml

Product Storage:   -70oC

References:
Boussiotis VA, et.al. R24 anti-GD3 ganglioside antibody can induce costimulation and prevent the induction of alloantigen-specific T cell clonal anergy. Eur J Immunolo 26:2149-2154, 1996

Houghton AN, et.al. Mouse Monoclonal IgG3 antibody detecting GD3 ganglioside: a phase I trial in patients with malignant melanoma. Proc Natl Acad Sci USA 82: 1242-1246, 1985

Welt S et.al. Immune and nonimmune effector functions of IgG3 mouse monoclonal antibody R24 detecting the disaloganglioside GD3 on the surface of melanoma cells. Clin Immunol Immnuopathol 45: 214-229, 1987

CAUTION: FOR RESEARCH USE ONLY.   NOT FOR DRUG OR DIAGNOSTIC USE. NOT FOR USE IN HUMANS.

NOTE: Recipients of bulk cytokines and monoclonal antibodies will be required to sign a Material Transfer Agreement. All International Orders are required to pay a packaging and handling fee. All recipients are required to providea a FedEx account number. All recipients are required to pay for shipping.