||2 ml (1 mg/ml in 4% mannitol, 100 mM arginine, 5 mM citric acid, 0.01% Tween 80, pH 7)
||Colorless, clear to slightly opalescent
||Non-reduced – one band at 187.4 kDa
Reduced – Heavy chain at 62.7 kDa, Light chain at 28.8 kDa
||Recombinant immunocyokine consisting of humanized monocolonal antibody (IgG1) against disialoganglioside (GD2 antigen) expressed with the IL2 cytokine on the C-terminal of the heavy chain subunits.
||Binds to GD-2 positive cells.
IL2 activity comparable to reference standard.
Endotoxin (<3 EU/mg protein)
Rabbit pyrogen (non-pyrogenic at dosage of 0.4 mg/kg body weight)
pH 7.0 ±0.4
|There will be a 5-day delay in processing requests that include this material. Initial approval by EMD Pharmaceutical, the donor of the reagent, is required prior to NCI’s release for shipment. Distribution of this reagent is limited to 3 vials per year per investigator.
|Address questions or comments to:
Biological Resources Branch
NCI-Frederick Cancer Research and Development Center
PO Box B
Building 1052, Room 253
Frederick, MD 21702