Event Description

Proteostasis, or protein homeostasis, is essential to maintain cellular function, and the disturbance of proteostasis is associated with many diseases in the list of leading causes of death, including neurodegenerative diseases, aging, and cancer. Cancer cells can usurp cellular regulatory machineries that governs physiological proteostasis to circumvent selection pressure posed by either microenvironment or therapeutic interventions. This journal club will focus on the current biomedical approach in controlling protein quality and quantity in cancer biology and also discuss complex human conditions where protein homeostasis is disrupted. By completion of this journal club, attendees will have developed an understanding of common mechanisms of proteostasis in regulation of human diseases and learned how to read a scientific publication.