Event Series

NIH Biomedical Engineering Special Interest Group Seminar Series (BME-SIG)

Event Description

The development, progression, and therapy response of cancer is determined by the evolution of intratumor heterogeneity. How extracellular matrix (ECM) remodeling regulates the phenotypic diversity of tumor and stromal cells and which consequences these changes have on malignancy, however, remains poorly understood. Increasing knowledge of these connections is critical as aberrant ECM remodeling often precedes tumor development (e.g. during obesity), regulates many different hallmarks of cancer including proliferation, metabolism, and angiogenesis, and can be used to diagnose and treat cancer more effectively. Studying the functional links between ECM remodeling and cancer requires model systems that allow isolating the physicochemical heterogeneity of malignancy-associated ECM for mechanistic studies. In this talk.

Hosted By

BME-SIG

Sponsored By

Laboratory of Cancer Immunometabolism

Tags

• Lecture