When
Thursday, November 29, 2018
10:00 AM - 11:00 AM
Where
NCI at Frederick, 376 Conference Room 121
Event Type
Seminar
Event Description
Chemical Tools for Tailoring Glycan Interactions at the Cell-Matrix Interface
Glycans (also known as carbohydrates, saccharides or, simply, sugars) are among the most intriguing carriers of biological information in living systems. The structures of glycans not only convey the cells’ physiological state, but also regulate cellular communication and responses by engaging receptors on neighboring cells and in the extracellular matrix. Despite their structural complexity, individual glycans rarely engage their protein partners with high affinity. Yet, glycans modulate biological processes with exquisite selectivity and specificity. To correctly evaluate glycan interactions and their biological consequences, one needs to look beyond individual glycan structures and consider the entirety of the cell-surface landscape. There, glycans...