Thursday, December 13, 2018
10:00 AM - 11:00 AM
NCI at Frederick, 376 Conference Room 121
New Tools for Studying Epigenetic Protein-Protein Interactions
Lysine and arginine methylation are common post-translational modifications (PTMs) of histone proteins that regulate gene transcription. Moreover, dysregulation of these PTMs has been implicated in many types of cancer. However, detection and characterization of these PTMs and evaluating the enzyme activity of the enzymes that install and remove them is still a challenge. We have developed three novel approaches to address these challenges. The first uses indicator displacement assays in a sensor array to report on multiple PTMs within the same peptide. Details of this work will be described...