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Sex-Based Differences in Human Immunodeficiency Virus Type 1 Reservoir Activity and Residual Immune Activation

  1. Author:
    Scully, Eileen P.
    Gandhi, Monica
    Johnston, Rowena
    Hoh, Rebecca
    Lockhart, Ainsley
    Dobrowolski, Curtis
    Pagliuzza, Amelie
    Milush, Jeffrey M.
    Baker, Christopher A.
    Girling, Valerie
    Ellefson, Arlvin
    Gorelick,Robert
    Lifson,Jeffrey
    Altfeld, Marcus
    Alter, Galit
    Cedars, Marcelle
    Solomon, Ajantha
    Lewin, Sharon R.
    Karn, Jonathan
    Chomont, Nicolas
    Bacchetti, Peter
    Deeks, Steven G.

  2. Author Address

    MIT, Ragon Inst, Massachusetts Gen Hosp, Cambridge, MA 02139 USA.Harvard Univ, Cambridge, MA 02138 USA.Brigham & Womens Hosp, Div Infect Dis, 75 Francis St, Boston, MA 02115 USA.Johns Hopkins Univ, Sch Med, Dept Med, Div Infect Dis, Baltimore, MD 21205 USA.Univ Calif San Francisco, Dept Med, San Francisco, CA 94143 USA.Fdn AIDS Res, amfAR, New York, NY USA.Case Western Reserve Univ, Cleveland, OH 44106 USA.Ctr Hosp Univ Montreal, Res Ctr, Montreal, PQ, Canada.Univ Montreal, Montreal, PQ, Canada.Leidos Biomedical Res Inc, Frederick Natl Lab Canc Res, AIDS & Canc Virus Program, Frederick, MD USA.Heinrich Pette Inst, Hamburg, Germany.Univ Calif San Francisco, Dept Obstet Gynecol & Reprod Sci, San Francisco, CA 94143 USA.Univ Melbourne, Peter Doherty Inst Infect & Immun, Melbourne, Vic, Australia.Royal Melbourne Hosp, Melbourne, Vic, Australia.Alfred Hosp, Dept Infect Dis, Melbourne, Vic, Australia.Monash Univ, Melbourne, Vic, Australia.Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA 94143 USA.
    1. Year: 2019
    2. Date: Apr 1
    3. Epub Date: 2018 10 29
  2. Journal: The Journal of infectious diseases
  3. OXFORD UNIV PRESS INC,
    1. 219
    2. 7
    3. Pages: 1084-1094
  5. Type of Article: Article
  6. ISSN: 0022-1899
  1. Abstract:

    Plasma human immunodeficiency virus type 1 (HIV-1) RNA levels in women are lower early in untreated HIV-1 infection compared with those in men, but women have higher T-cell activation and faster disease progression when adjusted for viral load. It is not known whether these sex differences persist during effective antiretroviral therapy (ART), or whether they would be relevant for the evaluation and implementation of HIV-1 cure strategies. We prospectively enrolled a cohort of reproductive-aged women and matched men on suppressive ART and measured markers of HIV-1 persistence, residual virus activity, and immune activation. The frequency of CD4(+) T cells harboring HIV-1 DNA was comparable between the sexes, but there was higher cell-associated HIV-1 RNA, higher plasma HIV-1 (single copy assay), and higher T-cell activation and PD-1 expression in men compared with women. These sex-related differences in immune phenotype and HIV-1 persistence on ART have significant implications for the design and measurement of curative interventions.

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External Sources

  1. View Full Text
  2. DOI: 10.1093/infdis/jiy617
  3. PMID: 30371873
  4. View record in Web of Science®
  5. WOS: 000472805600010

Library Notes

  1. Fiscal Year: FY2018-2019
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