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Association of HPV35 with cervical carcinogenesis among women of African ancestry: evidence of viral-host interaction with implications for disease intervention

  1. Author:
    Pinheiro, Maisa [ORCID]
    Gage, Julia C
    Clifford, Gary M [ORCID]
    Demarco, Maria
    Cheung, Li C
    Chen, Zigui
    Yeager,Meredith
    Cullen,Michael
    Boland,Joseph
    Chen, Xiaojian
    Raine-Bennett, Tina
    Steinberg,Mia
    Bass,Sara
    Befano, Brian
    Xiao, Yanzi
    Tenet, Vanessa
    Walker, Joan
    Zuna, Rosemary
    Poitras, Nancy E
    Gold, Michael A
    Dunn, Terence
    Yu, Kai
    Zhu, Bin
    Burdett,Laurie
    Turan,Sevilay
    Lorey, Thomas
    Castle, Philip E
    Wentzensen, Nicolas [ORCID]
    Burk, Robert D [ORCID]
    Schiffman, Mark
    Mirabello, Lisa

  2. Author Address

    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD., International Agency for Research on Cancer 150, Cours Albert Thomas, F-69372 Lyon cedex 08, France., Department of Microbiology, The Chinese University of Hong Kong, Hong Kong., Cancer Genomics Research Laboratory, Leidos Biomedical Research, Inc., Frederick, Maryland., Division of Research, Kaiser Permanente Northern California, Oakland, CA., Information Management Services, Calverton, MD., University of Oklahoma Health Sciences Center, Oklahoma City, OK., Regional Laboratory, Kaiser Permanente Northern California, Berkeley, CA., Department of Obstetrics and Gynecology, Vanderbilt University, Nashville, Tennessee., Department of Pathology, The University of Oklahoma Health Science Center, Oklahoma City, OK., Regional Laboratory and Women 39;s Health Research Institute, Division of Research, Kaiser Permanente Northern California, Oakland, CA., Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY., Departments of Pediatrics, Microbiology and Immunology, and Obstetrics & Gynecology and Women 39;s Health, Albert Einstein College of Medicine, Bronx, NY.,
    1. Year: 2020
    2. Date: MAY 16
    3. Epub Date: 2020 05 04
  2. Journal: International journal of cancer
  4. Type of Article: Article
  5. ISSN: 0020-7136
  1. Abstract:

    HPV35 has been found in only similar to 2% of invasive cervical cancers (ICC) worldwide but up to 10% in Sub-Saharan Africa, warranting further investigation and consideration of impact on preventive strategies. We studied HPV35 and ethnicity, in relation to the known steps in cervical carcinogenesis, using multiple large epidemiologic studies in the U.S. and internationally. Combining five U.S. studies, we measured HPV35 positivity and, in Northern California, observed HPV35 type-specific population prevalence and estimated 5-year risk of developing precancer when HPV35-positive. HPV35 genetic variation was examined for differences in carcinogenicity in 1053 HPV35+ cervical specimens from a U.S. cohort and an international collection. African-American women had more HPV35 (12.1% vs 5.1%, P < .001) and more HPV35-associated precancers (7.4% vs 2.1%, P < .001) compared to other ethnicities. Precancer risks after HPV35 infection did not vary by ethnicity (global P = .52). The HPV35 A2 sublineage showed an increased association with precancer/cancer in African-Americans (OR = 5.6 vs A1, 95% CI = 1.3-24.8) and A2 was more prevalent among ICC in Africa than other world regions (41.9% vs 10.4%, P < .01). Our analyses support a strong link between HPV35 and cervical carcinogenesis in women of African ancestry. Current HPV vaccines cover the majority of cervical precancer/cancer across all ethnic groups; additional analyses are required to determine whether the addition of HPV35 to the already highly effective nine-valent HPV vaccine would provide better protection for women in Africa or of African ancestry.

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External Sources

  1. View Full Text
  2. DOI: 10.1002/ijc.33033
  3. PMID: 32363580
  4. View record in Web of Science®
  5. WOS: 000532983000001

Library Notes

  1. Fiscal Year: FY2019-2020
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