Skip NavigationSkip to Content
Return Return to Search Results

A high-density admixture map for disease gene discovery in African Americans

  1. Author:
    Smith, M. W.
    Patterson, N.
    Lautenberger, J. A.
    Truelove, A. L.
    McDonald, G. J.
    Waliszewska, A.
    Kessing, B. D.
    Malasky, M. J.
    Scafe, C.
    Le, E.
    De Jager, P. L.
    Mignault, A. A.
    Yi, Z.
    de The, G.
    Essex, M.
    Sankale, J. L.
    Moore, J. H.
    Poku, K.
    Phair, J. P.
    Goedert, J. J.
    Vlahov, D.
    Williams, S. M.
    Tishkoff, S. A.
    Winkler, C. A.
    De La Vega, F. M.
    Woodage, T.
    Sninsky, J. J.
    Hafler, D. A.
    Altshuler, D.
    Gilbert, D. A.
    O'Brien, S. J.
    Reich, D.

  2. Author Address

    Reich, D, Harvard Univ, Sch Med, Dept Genet, New Res Bldg,77 Ave Louis Pasteur, Boston, MA 02115 USA Harvard Univ, Sch Med, Dept Genet, Boston, MA 02115 USA. NCI, Lab Genom Divers, Frederick, MD 21701 USA. NCI, Basic Res Program, Sci Applicat Int Corp, Frederick, MD 21701 USA. Broad Inst, Program Med & Populat Genet, Cambridge, MA USA. Harvard Univ, Sch Med, Lab Mol Immunol, Boston, MA USA. Brigham & Womens Hosp, Ctr Neurol Dis, Boston, MA 02115 USA. Harvard Univ, Sch Publ Hlth, Harvard AIDS Inst, Boston, MA 02115 USA. Harvard Univ, Sch Publ Hlth, Dept Immunol & Infect Dis, Boston, MA 02115 USA. Massachusetts Gen Hosp, Dept Med, Boston, MA 02114 USA. Massachusetts Gen Hosp, Dept Mol Biol, Boston, MA 02114 USA. Appl Biosyst Inc, Foster City, CA 94404 USA. Chinese Acad Prevent Med, Inst Virol, Beijing 100052, Peoples R China. Inst Pasteur, CNRS, Dept Viral Oncol Epidemiol, Paris, France. Vanderbilt Univ, Ctr Human Genet Res, Nashville, TN USA. Vanderbilt Univ, Dept Med, Div Cardiovasc Med, Nashville, TN USA. Vanderbilt Univ, Dept Physiol & Mol Biophys, Nashville, TN USA. Univ Ghana, Sch Adm, Legon, Ghana. Northwestern Univ, Howard Brown Hlth Ctr, Chicago, IL 60611 USA. Northwestern Univ, Dept Med, Chicago, IL 60611 USA. NCI, Viral Epidemiol Branch, Div Canc Epidemiol & Genet, Rockville, MD USA. New York Acad Med, Ctr Urban Epidemiol Studies, New York, NY USA. Univ Maryland, Dept Biol, College Pk, MD 20742 USA. Celera Diagnost, Alameda, CA USA.
    1. Year: 2004
  2. Journal: American Journal of Human Genetics
    1. 74
    2. 5
    3. Pages: 1001-1013
  4. Type of Article: Article
  1. Abstract:

    Admixture mapping ( also known as "mapping by admixture linkage disequilibrium," or MALD) provides a way of localizing genes that cause disease, in admixed ethnic groups such as African Americans, with similar to100 times fewer markers than are required for whole-genome haplotype scans. However, it has not been possible to perform powerful scans with admixture mapping because the method requires a dense map of validated markers known to have large frequency differences between Europeans and Africans. To create such a map, we screened through databases containing similar to450,000 single-nucleotide polymorphisms (SNPs) for which frequencies had been estimated in African and European population samples. We experimentally confirmed the frequencies of the most promising SNPs in a multiethnic panel of unrelated samples and identified 3,011 as a MALD map (1.2 cM average spacing). We estimate that this map is similar to70% informative in differentiating African versus European origins of chromosomal segments. This map provides a practical and powerful tool, which is freely available without restriction, for screening for disease genes in African American patient cohorts. The map is especially appropriate for those diseases that differ in incidence between the parental African and European populations

    See More

  1. Keywords:

External Sources

  1. No sources found.

Library Notes

  1. No notes added.
NCI at Frederick

You are leaving a government website.

This external link provides additional information that is consistent with the intended purpose of this site. The government cannot attest to the accuracy of a non-federal site.

Linking to a non-federal site does not constitute an endorsement by this institution or any of its employees of the sponsors or the information and products presented on the site. You will be subject to the destination site's privacy policy when you follow the link.

ContinueCancel