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Susceptibility to astrocytoma in mice mutant for Nf1 and Trp53 is linked to chromosome 11 and subject to epigenetic effects

  1. Author:
    Reilly, K. M.
    Tuskan, R. G.
    Christy, E.
    Loisel, D. A.
    Ledger, J.
    Bronson, R. T.
    Smith, C. D.
    Tsang, S.
    Munroe, D. J.
    Jacks, T.

  2. Author Address

    NCI, Mouse Canc Genet Program, Ft Detrick, MD 21702 USA. MIT, Dept Biol, Cambridge, MA 02169 USA. MIT, Ctr Canc Res, Cambridge, MA 02169 USA. MIT, Howard Hughes Med Inst, Cambridge, MA 02169 USA. Harvard Univ, Sch Med, Dept Pathol, Boston, MA 02115 USA. Sci Applicat Int Corp, Lab Anim Sci Program, Ft Detrick, MD 21702 USA. Sci Applicat Int Corp, Lab Mol Technol, Ft Detrick, MD 21702 USA Reilly, KM, NCI, Mouse Canc Genet Program, Ft Detrick, MD 21702 USA
    1. Year: 2004
    2. Date: AUG 31
  2. Journal: Proceedings of the National Academy of Sciences of the United States of America
    1. 101
    2. 35
    3. Pages: 13008-13013
  4. Type of Article: Article
  1. Abstract:

    Astrocytoma is the most common malignant brain tumor in humans. Loss of the p53 signaling pathway and up-regulation of the ras signaling pathway are common during tumor progression. We have shown previously that mice mutant for Trp53 and NO develop astrocytoma, progressing to glioblastoma, on a C57BL/6J strain background. In contrast, here we present data that mice mutant for Trp53 and Nf1 on a 129S4/SvJae background are highly resistant to developing astrocytoma. Through analysis of F-1 progeny, we demonstrate that susceptibility to astrocytoma is linked to chromosome 11, and that the modifier gene(s) responsible for differences in susceptibility is closely linked to Nf1 and Trp53. Furthermore, this modifier of astrocytoma susceptibility is itself epigenetically modified. These data demonstrate that epigenetic effects can have a strong effect on whether cancer develops in the context of mutant ras signaling and mutant p53, and that this mouse model of astrocytoma can be used to identify modifier phenotypes with complex inheritance patterns that would be unidentifiable in humans. Because analysis of gene function in the mouse is often performed on a mixed C57BL/6,129 strain background, these data also provide a powerful example of the potential of these strains to mask interesting gene functions

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External Sources

  1. View record in Web of Science®
  2. WOS: 000223694700043

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