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Repeat-region polymorphisms in the gene for the dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin related molecule: Effects on HIV-1 susceptibility

  1. Author:
    Liu, H. L.
    Carrington, M.
    Wang, C. H.
    Holte, S.
    Lee, J.
    Greene, B.
    Hladik, F.
    Koelle, D. M.
    Wald, A.
    Kurosawa, K.
    Rinaldo, C. R.
    Celum, C.
    Detels, R.
    Corey, L.
    McElrath, M. J.
    Zhu, T. F.

  2. Author Address

    Univ Washington, Sch Med, Dept Lab Med, Seattle, WA 98195 USA. Univ Washington, Sch Med, Dept Med, Seattle, WA 98195 USA. Univ Washington, Sch Med, Dept Microbiol, Seattle, WA 98195 USA. Fred Hutchinson Canc Res Ctr, Program Infect Dis, Seattle, WA 98104 USA. Fred Hutchinson Canc Res Ctr, Program Biostat, Seattle, WA 98104 USA. NCI, Basic Res Program, Sci Applicat Int Corp, Lab Genom Divers, Frederick, MD 21701 USA. Univ Pittsburgh, Sch Publ Hlth, Dept Infect Dis & Microbiol, Pittsburgh, PA 15260 USA. Univ Calif Los Angeles, Sch Publ Hlth, Los Angeles, CA 90024 USA.;Zhu, TF, Univ Washington, Sch Med, Dept Lab Med, Box 358070,1959 NE Pacific St, Seattle, WA 98195 USA.;tzhu@u.washington.edu
    1. Year: 2006
    2. Date: Mar
  2. Journal: Journal of Infectious Diseases
    1. 193
    2. 5
    3. Pages: 698-702
  4. Type of Article: Article
  5. ISSN: 0022-1899
  1. Abstract:

    In 1716 individuals-801 human immunodeficiency virus (HIV)-1-seropositive individuals, 217 high-risk HIV-1-seronegative individuals, and 698 general HIV-1-seronegative individuals-from a Seattle cohort and a Multicenter AIDS Cohort Study cohort, the association between HIV1 susceptibility and repeat-region polymorphisms in the gene for the dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin-related molecule (DC-SIGNR) was investigated; 16 genotypes were found in the DC-SIGNR repeat region. The DC-SIGNR homozygous 7/7 repeat was found to be associated with an increased risk of HIV-1 infection (17.5% in high-risk HIV-1-seronegative individuals vs. 28.5% in HIV-1-seropositive individuals;), whereas the DC-SIGNR heterozygous 7/5 repeat Pp. 0015 tended to be correlated with resistance to HIV-1 infection (35.5% in high-risk HIV-1-seronegative individuals vs. 27.6% in HIV-1-seropositive individuals;). These Pp. 0291 findings suggest that DC-SIGNR polymorphisms may influence susceptibility to HIV-1.

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External Sources

  1. View record in Web of Science®
  2. WOS: 000235535500012

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