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A novel proteoliposomal vaccine induces antitumor immunity against follicular lymphoma

  1. Author:
    Neelapu, S. S.
    Gause, B. L.
    Harvey, L.
    Lee, S. T.
    Frye, A. R.
    Horton, J.
    Robb, R. J.
    Popescu, M. C.
    Kwak, L. W.

  2. Author Address

    Univ Texas, MD Anderson Canc Ctr, Dept Lymphoma & Myeloma, Houston, TX 77030 USA. NIH, Ctr Canc Res, Expt & Transplantat Immunol Branch, Bethesda, MD 20892 USA. NCI, SAIC, Frederick, MD 21701 USA. XEME Biopharma Inc, Plainsboro, NJ USA.;Neelapu, SS, Univ Texas, MD Anderson Canc Ctr, Dept Lymphoma & Myeloma, 1515 Holcombe Blvd, Houston, TX 77030 USA.
    1. Year: 2007
    2. Date: Jun
  2. Journal: Blood
    1. 109
    2. 12
    3. Pages: 5160-5163
  4. Type of Article: Article
  5. ISSN: 0006-4971
  1. Abstract:

    Clinical studies suggest that treatment with vaccines comprised of idlotype protein may be associated with improved clinical outcome in follicular lymphoma patients. The time-consuming process required to generate patient-specific vaccines is a major limitation, however. Here we report results of a pilot clinical trial with a novel autologous, tumor-derived proteoliposome vaccine formulation that could be rapidly produced within a single day. Vaccination was safe, induced autologous tumor-specific type 1 cytokine responses in 5 out of 10 follicular lymphoma patients, and was associated with induction of a sustained complete response in one patient. Other patients had large tumor burdens and progressed after a median duration of 8 months. These results suggest that further testing of this vaccine formulation, particularly in the setting of minimal disease, is warranted. Furthermore, the proteoliposome formulation may provide a model for vaccine development for other human cancers, for which tumor-associated antigens need not be defined.

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External Sources

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  2. DOI: 10.1182/blood-2006-12-063594
  3. View record in Web of Science®
  4. WOS: 000247360200024

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