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Four independent mutations in the feline Fibroblast Growth Factor 5 gene determine the long-haired phenotype in domestic cats

  1. Author:
    Kehler, J. S.
    David, V. A.
    Schaffer, A. A.
    Bajema, K.
    Eizirik, E.
    Ryugo, D. K.
    Hannah, S. S.
    O'Brien, S. J.
    Menotti-Raymond, M.
  2. Author Address

    Natl Canc Inst, Lab Genom Diversity, Frederick, MD 21702 USA. Univ Penn, Sch Vet Med, Ctr Anim Transgenesis & Germ Cell Res, Kennett Sq, PA 19348 USA. Natl Inst Hlth, Dept Hlth & Human Serv, Natl Ctr Biotechnol Informat, Bethesda, MD 20894 USA. Pontificia Univ Catolica Rio do Grande Sul, Fac Biociencias, Ctr Biol Genom & Mol, BR-90619900 Porto Alegre, RS, Brazil. Johns Hopkins Univ, Dept Otolaryngol & Neurosci, Baltimore, MD 21205 USA. Nestle Purina PetCare Co, St Louis, MO 63134 USA.;Kehler, JS, Natl Canc Inst, Lab Genom Diversity, Frederick, MD 21702 USA.;jkehler@ncifcrf.gov
    1. Year: 2007
    2. Date: Sep-Oct
  1. Journal: Journal of Heredity
    1. 98
    2. 6
    3. Pages: 555-566
  2. Type of Article: Article
  3. ISSN: 0022-1503
  1. Abstract:

    To determine the genetic regulation of "hair length" in the domestic cat, a whole-genome scan was performed in a multigenerational pedigree in which the "long-haired" phenotype was segregating. The 2 markers that demonstrated the greatest linkage to the long-haired trait (log of the odds >= 6) flanked an estimated 10-Mb region on cat chromosome B1 containing the Fibroblast Growth Factor 5 (FGF5) gene, a candidate gene implicated in regulating hair follicle growth cycle in other species. Sequence analyses of FGF5 in 26 cat breeds and 2 pedigrees of nonbreed cats revealed 4 separate mutations predicted to disrupt the biological activity of the FGF5 protein. Pedigree analyses demonstrated that different combinations of paired mutant FGF5 alleles segregated with the long-haired phenotype in an autosomal recessive manner. Association analyses of more than 380 genotyped breed and nonbreed cats were consistent with mutations in the FGF5 gene causing the long-haired phenotype in an autosomal recessive manner. In combination, these genomic approaches demonstrated that FGF5 is the major genetic determinant of hair length in the domestic cat.

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External Sources

  1. DOI: 10.1093/jhered/esm072
  2. WOS: 000250009200001

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