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Cytotoxic and HIF-1alpha inhibitory compounds from Crossosoma bigelovii

  1. Author:
    Klausmeyer, P.
    Zhou, Q.
    Scudiero, D. A.
    Uranchimeg, B.
    Melillo, G.
    Cardellina, J. H.
    Shoemaker, R. H.
    Chang, C. J.
    McCloud, T. G.

  2. Author Address

    Natural Products Support Group, SAIC-Frederick, Inc, NCI-Frederick, Frederick, Maryland 21702, USA.
    1. Year: 2009
    2. Date: May 22
    3. Epub Date: 5/2/2009
  2. Journal: Journal of Natural Products
    1. 72
    2. 5
    3. Pages: 805-12
  4. Type of Article: Article
  5. ISSN: 1520-6025 (Electronic);0163-3864 (Linking)
  1. Abstract:

    Cytotoxicity-guided fractionation of an organic solvent extract of the plant Crossosoma bigelovii led to the discovery of a new strophanthidin glycoside (1) and two new 2-methylchromone glycosides (2 and 3). Also isolated were the known chromones eugenin and noreugenin, the indole alkaloid ajmalicine, the dibenzylbutane lignan secoisolariciresinol, the dibenzylbutyrolactone lignan matairesinol, and the furanone 5-tetradec-5-enyldihydrofuran-2-one. Further investigation into the biological properties of strophanthidin glycosides revealed a connection between inhibition of HIF-1 activation and the glycosylation of the genin. This work is the first published study of the bioactive phytochemicals of the family Crossosomataceae.

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External Sources

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  2. DOI: 10.1021/np8006342
  3. PMID: 19405508

Library Notes

  1. Fiscal Year: FY2008-2009
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