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Decreased Prevalence of Lymphatic Filariasis among Diabetic Subjects Associated with a Diminished Pro-Inflammatory Cytokine Response (CURES 83)

  1. Author:
    Aravindhan, V.
    Mohan, V.
    Surendar, J.
    Rao, M. M.
    Pavankumar, N.
    Deepa, M.
    Rajagopalan, R.
    Kumaraswami, V.
    Nutman, T. B.
    Babu, S.

  2. Author Address

    [Aravindhan, Vivekanandhan; Mohan, Viswanathan; Surendar, Jayagopi; Rao, Maradana Muralidhara; Deepa, Mohan; Rajagopalan, Ramanujam] Madras Diabet Res Fdn, Madras, Tamil Nadu, India. [Mohan, Viswanathan] Dr Mohans Diabet Specialties Ctr, Madras, Tamil Nadu, India. [Pavankumar, Nathella; Babu, Subash] Int Ctr Excellence Res, Natl Inst Hlth, Madras, Tamil Nadu, India. [Kumaraswami, Vasanthapuram] TB Res Ctr, Madras, Tamil Nadu, India. [Nutman, Thomas B.] NIAID, Parasit Dis Lab, NIH, Bethesda, MD 20892 USA. [Babu, Subash] NCI, SAIC Frederick Inc, Frederick, MD 21701 USA.;Aravindhan, V, Madras Diabet Res Fdn, Madras, Tamil Nadu, India.;cvaravindhan@yahoo.co.uk
    1. Year: 2010
    2. Date: Jun
  2. Journal: Plos Neglected Tropical Diseases
    1. 4
    2. 6
    3. Pages: 6
  4. Type of Article: Article
  5. Article Number: e707
  6. ISSN: 1935-2727
  1. Abstract:

    Epidemiological studies have shown an inverse correlation between the incidence of lymphatic filariasis (LF) and the incidence of allergies and autoimmunity. However, the interrelationship between LF and type-2 diabetes is not known and hence, a cross sectional study to assess the baseline prevalence and the correlates of sero-positivity of LF among diabetic subjects was carried out (n = 1416) as part of the CURES study. There was a significant decrease in the prevalence of LF among diabetic subjects (both newly diagnosed [5.7%] and those under treatment [4.3%]) compared to pre-diabetic subjects [9.1%] (p = 0.0095) and non-diabetic subjects [10.4%] (p = 0.0463). A significant decrease in filarial antigen load (p = 0.04) was also seen among diabetic subjects. Serum cytokine levels of the pro-inflammatory cytokines-IL-6 and GM-CSF-were significantly lower in diabetic subjects who were LF positive, compared to those who were LF negative. There were, however, no significant differences in the levels of anti-inflammatory cytokines-IL-10, IL-13 and TGF-beta-between the two groups. Although a direct causal link has yet to be shown, there appears to be a striking inverse relationship between the prevalence of LF and diabetes, which is reflected by a diminished pro-inflammatory cytokine response in Asian Indians with diabetes and concomitant LF.

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External Sources

  1. View Full Text
  2. DOI: 10.1371/journal.pntd.0000707
  3. View record in Web of Science®
  4. WOS: 000279341300016

Library Notes

  1. Fiscal Year: FY2009-2010
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