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Structure of the cytoplasmic domain of Yersinia pestis YscD, an essential component of the type III secretion system

  1. Author:
    Lountos, G. T.
    Tropea, J. E.
    Waugh, D. S.

  2. Author Address

    [Lountos, George T.; Tropea, Joseph E.; Waugh, David S.] NCI, Macromol Crystallog Lab, Ctr Canc Res, Frederick, MD 21702 USA. [Lountos, George T.] NCI, Basic Sci Program, SAIC Frederick Inc, Frederick, MD 21702 USA.;Waugh, DS (reprint author), NCI, Macromol Crystallog Lab, Ctr Canc Res, Frederick, MD 21702 USA;waughd@mail.nih.gov
    1. Year: 2012
    2. Date: Mar
  2. Journal: Acta Crystallographica Section D-Biological Crystallography
    1. 68
    2. Pages: 201-209
  4. Type of Article: Article
  5. ISSN: 0907-4449
  1. Abstract:

    The Yersinia pestis YscD protein is an essential component of the type III secretion system. YscD consists of an N-terminal cytoplasmic domain (residues 1-121), a transmembrane linker (122-142) and a large periplasmic domain (143-419). Both the cytoplasmic and the periplasmic domains are required for the assembly of the type III secretion system. Here, the structure of the YscD cytoplasmic domain solved by SAD phasing is presented. Although the three-dimensional structure is similar to those of forkhead-associated (FHA) domains, comparison with the structures of canonical FHA domains revealed that the cytoplasmic domain of YscD lacks the conserved residues that are required for binding phosphothreonine and is therefore unlikely to function as a true FHA domain.

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External Sources

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  2. DOI: 10.1107/s0907444911054308
  3. View record in Web of Science®
  4. WOS: 000300444300001

Library Notes

  1. Fiscal Year: FY2011-2012
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