Skip NavigationSkip to Content
Return Return to Search Results

Unusual Vilasinin-Class Limonoids from Trichilia rubescens

  1. Author:
    Amuti, Saidanxia
    Saito, Yohei
    Fukuyoshi, Shuichi [ORCID]
    Miyake, Katsunori [ORCID]
    Newman,Dave
    O'Keefe,Barry [ORCID]
    Lee, Kuo-Hsiung [ORCID]
    Nakagawa-Goto, Kyoko [ORCID]

  2. Author Address

    School of Pharmaceutical Sciences, College of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa 920-1192, Japan., School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Hachioji 192-0392, Japan., Natural Products Branch, Developmental Therapeutics Program, Center of Cancer Research, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Frederick, MD 21702-1201, USA., Molecular Targets Program, Center for Cancer Research, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Frederick, MD 21702-1201, USA., Natural Products Research Laboratories, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7568, USA., Chinese Medicine Research and Development Center, China Medical University and Hospital, 2 Yuh-Der Road, Taichung 40447, Taiwan.,
    1. Year: 2024
    2. Date: Jan 30
    3. Epub Date: 2024 01 30
  2. Journal: Molecules (Basel, Switzerland)
    1. 29
    2. 3
  4. Type of Article: Article
  5. Article Number: 651
  1. Abstract:

    Eight vilasinin-class limonoids, including the unusually chlorinated rubescins K-M (1-3), the 2,3-epoxylated rubescin N (4), and rubescins O-R (5-8), were newly isolated from Trichilia rubescens. The structures of the isolated compounds were determined through spectroscopic and spectrometric analyses, as well as ECD calculations. The natural occurrence of chlorinated limonoids 1-3 was confirmed by chemical methods and HPLC analysis of a roughly fractionated portion of the plant extract. Eight selected limonoids, including previously known and new compounds, were evaluated for antiproliferative activity against five human tumor cell lines. All tested limonoids, except 8, exhibited significant potency, with IC50 values of <10 µM; in particular, limonoid 14 strongly inhibited tumor cell growth, with IC50 values of 0.54-2.06 µM against all tumor cell lines, including multi-drug-resistant cells.

    See More

  1. Keywords:

External Sources

  1. View Full Text
  2. DOI: 10.3390/molecules29030651
  3. PMID: 38338394
  4. PMCID: PMC10856392
  5. PII : molecules29030651

Library Notes

  1. Fiscal Year: FY2023-2024
NCI at Frederick

You are leaving a government website.

This external link provides additional information that is consistent with the intended purpose of this site. The government cannot attest to the accuracy of a non-federal site.

Linking to a non-federal site does not constitute an endorsement by this institution or any of its employees of the sponsors or the information and products presented on the site. You will be subject to the destination site's privacy policy when you follow the link.

ContinueCancel