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Translocation by multi-subunit RNA polymerases

  1. Author:
    Kireeva, M.
    Kashlev, M.
    Burton, Z. F.

  2. Author Address

    [Burton, Zachary F.] Michigan State Univ, Dept Biochem & Mol Biol, E Lansing, MI 48824 USA. [Kireeva, Maria; Kashlev, Mikhail] Natl Canc Inst Frederick, Gene Regulat & Chromosome Biol Lab, Frederick, MD 21702 USA.;Burton, ZF, Michigan State Univ, Dept Biochem & Mol Biol, E Lansing, MI 48824 USA.;burton@cns.msu.edu
    1. Year: 2010
    2. Date: May-Jun
  2. Journal: Biochimica Et Biophysica Acta-Gene Regulatory Mechanisms
    1. 1799
    2. 5-6
    3. Pages: 389-401
  4. Type of Article: Review
  5. ISSN: 1874-9399
  1. Abstract:

    DNA template and RNA/DNA hybrid movement through RNA polymerase (RNAP) is referred to as "translocation". Because nucleic acid movement is coupled to NTP loading, pyrophosphate release, and conformational changes, the precise ordering of events during bond addition is consequential. Moreover, based on several lines of experimental evidence, translocation, pyrophosphate release or an associated conformational change may determine the transcription elongation rate. In this review we discuss various models of translocation, the data supporting the hypothesis that translocation rate determines transcription elongation rate and also data that may be inconsistent with this point of view. A model of the nucleotide addition cycle accommodating available experimental data is proposed. On the basis of this model, the molecular mechanisms regulating translocation and potential routes for NIP entry are discussed. (C) 2010 Elsevier B.V. All rights reserved.

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External Sources

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  2. DOI: 10.1016/j.bbagrm.2010.01.007
  3. View record in Web of Science®
  4. WOS: 000278321400004

Library Notes

  1. Fiscal Year: FY2009-2010
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