Agenda

The symposium will feature our keynote speaker, Dr. Mark A. Lemmon, Yale University, and several talks selected from submitted abstracts. 

Dr. Mark Lemmon was appointed the Co-Director of the Cancer Biology Institute and the David A. Sackler Professor of Pharmacology in 2015. Dr. Lemmon returned to Yale, where he completed his Ph.D. in 1993, from the University of Pennsylvania’s Perelman School of Medicine. At the University of Pennsylvania, he was the George W. Raiziss Professor of Biochemistry and Biophysics as well as Chair of the department and an Investigator at the Abramson Family Cancer Research Institute. Dr. Lemmon’s research focuses on the signaling pathways of receptor tyrosine kinases (RTKs), which when mutated cause cancers and other diseases.

Friday, May 24, 2019

08:50 am - 09:00 am EST
Welcome Note and Introduction about the Center of Excellence in Integrative Cancer Biology and Genomics (CEICBG) symposiums
09:00 am - 09:20 am EST
MAP3K19: A Novel Activator of the MAPK Signaling Cascade

Van Barnes, Ph.D.
Laboratory of Cell and Developmental Signaling, Center for Cancer Research, NCI

09:20 am - 09:30 am EST
Introduction of Keynote Speaker
09:30 am - 10:30 am EST
Keynote Address: Allostery and Dynamics in Transmembrane Signaling by Growth Factor Receptor Tyrosine Kinases

Mark A. Lemmon, Ph.D.
David A. Sackler Professor of Pharmacology
Co-Director, Cancer Biology Institute
Yale University

10:30 am - 10:40 am EST
Break
10:40 am - 11:00 am EST
Role of Interferon Signaling in Metastatic Prostate Cancer

Supreet Agarwal, Ph.D.
Laboratory of Genitourinary Cancer Pathogenesis, Center for Cancer Research, NCI

11:00 am - 11:20 am EST
Small Molecule Stabilizers of the MYC G4-Quadruplex Induces Pyroptosis in Multiple Myeloma

Snehal Gaikwad, Ph.D.
Laboratory of Cancer Biology and Genetics, Center for Cancer Research, NCI

11:20 am - 11:40 am EST
Identification of TNIK as a Potential Therapeutic Target in Lung Squamous Cell Carcinoma

Pedro Torres-Ayuso, Ph.D.
Laboratory of Cell and Developmental Signaling, Center for Cancer Research, NCI

11:40 am - 12:00 pm EST
Proteomic Analyses of CRISPR-Edited FBXW7-Mutant Serous Endometrial Cancer Cell Lines

Mary Ellen Urick, Ph.D.
Reproductive Cancer Genetics Section, National Human Genome Research Institute, NIH

12:00 pm - 12:20 pm EST
Leucine Zipper-Bearing Kinase (LZK) is a Novel Therapeutic Target in Head and Neck Squamous Cell Carcinoma Patients with 3Q Amplification

Amy Funk, Ph.D.
Laboratory of Cell and Developmental Signaling, Center for Cancer Research, NCI

12:20 pm - 12:40 pm EST
LDB1 Is Required for LMO2 Oncogene-Induced Thymocyte Self-Renewal and T Cell Acute Lymphoblastic Leukemia

Liqi Li, M.D., Ph.D.
National Institute of Child Health and Human Development, NIH

12:40 pm - 12:45 pm EST
Closing Remarks