Agenda

Monday, May 20 Tuesday, May 21

Monday, May 20, 2019

09:00 am - 09:10 am EST
Welcome and Introductions

Douglas Lowy, M.D., Acting Director, NCI
Tom Misteli, Ph.D., Director, CCR
Stephen Chanock, M.D., Director, DCEG

Session 1:  Imaging and Radiation Research

09:10 am - 09:30 am EST
A Double Approach to Improve Radiotherapy Treatment: Enchancing the Efficancy with Dbait and Decreasing the Radiotoxicity with FLASH

Marie Dutreix, Ph.D.
Institut Curie

09:30 am - 09:50 am EST
Radiation-Induced Translational Control of Gene Expression

Philip Tofilon, Ph.D.
Center for Cancer Research

09:50 am - 10:10 am EST
Deep Learning and Automated Visual Screening of the Cervix

Mark Schiffman, Ph.D.
Division of Cancer Epidimiology and Genetics

10:10 am - 10:30 am EST
Senescence After Radiotherapy: Implications for Normal Tissues and Tumor

Debroah Citrin, M.D.
Center for Cancer Research

10:30 am - 10:50 am EST
Biologically-Guided Radiation Therapy with PET/MR Imaging

Giles Créhange, M.D.
Institut Curie

10:50 am - 11:10 am EST
Modification of Tumor Radiosensitivity Coupled with Molecular Imaging

James Mitchell, Ph.D.
Center for Cancer Research

11:10 am - 11:30 am EST
BREAK

Session 2:  Immunology

11:30 am - 11:50 am EST
Cellular Immunotherapy for Common Epithelial Cancers

Steven Rosenberg, M.D., Ph.D.
Center for Cancer Research

11:50 am - 12:10 pm EST
Impact of Tissue Physical cues on the Migration of Dendritic Cells

Ana-Maria Lennon, Ph.D.
Institut Curie

12:10 pm - 12:30 pm EST
Transcriptional Regulation of Neuroinflammation

Vanja Lazarevic, Ph.D.
Center for Cancer Research

12:30 pm - 01:30 pm EST
LUNCH

Session 2:  Immunology (continued)

01:30 pm - 01:50 pm EST
Mutations of the Splicing Factor SF3B1 Generate Public Immunogenic Epitopes in Uveal Melanoma

Olivier Lantz, Ph.D.
Institut Curie

01:50 pm - 02:10 pm EST
Chimeric Antigen Receptor T-cell Therapy for Hematologic Malignancies

James Kochenderfer, M.D.
Center for Cancer Research

Session 3:  Cancer Microenvironment

02:10 pm - 02:30 pm EST
Harnessing Immune and Stromal Plasticity in the Metastatic Niche

Rosie Kaplan, M.D.
Center for Cancer Research

02:30 pm - 02:50 pm EST
Role of Fibroblast Heterogeneity in Immunosupression and Metastatic Spread in Breast Cancers

Fatima Mechta-Grigoriou, Ph.D.
Institut Curie

02:50 pm - 03:10 pm EST
Microbiota: Key Modulator of the Tumor Microenvironment

Romina Goldszmid, Ph.D.
Center for Cancer Research

03:10 pm - 03:30 pm EST
BREAK
03:30 pm - 03:50 pm EST
Vessel Co-Option and Radioresistance in Glioblastoma

Giorgio Seano, Ph.D.
Institut Curie

03:50 pm - 04:10 pm EST
The Immune Landscape of Cancer: What Influences it?

Li Yang, Ph.D.
Center for Cancer Research

Tuesday, May 21, 2019

Session 4:  Chemical Biology

09:00 am - 09:20 am EST
Developing Materials for Drug Deliver and Surgical Procedures

Joel Schneider, Ph.D.
Center for Cancer Research

09:20 am - 09:40 am EST
Success Stories of the Curie-CNRS Chemical Library

Florence Mahuteau-Betzer, Ph.D.
Institut Curie

09:40 am - 10:00 am EST
Targeting Structurally and Functionally Diverse Nucleic Acids with Druglike Small Molecules

Jay Schneekloth, Ph.D.
Center for Cancer Research

10:00 am - 10:20 am EST
Prevalent Role of Iron in Cancer

Raphaë Rodriguez, Ph.D.
Institut Curie

10:20 am - 10:40 am EST
The NCI Program for Natural Product Discovery

Barry O’Keefe, Ph.D.
Center for Cancer Research

10:40 am - 11:00 am EST
BREAK

Session 5:  Physical Sciences

11:00 am - 11:20 am EST
Manipulating p53 Dynamics in Single Cells to Control Cell Fate

Eric Batchelor, Ph.D.
Center for Cancer Research

11:20 am - 11:40 am EST
Multiscale Rheology of Glioblastoma Cells

Jean-Baptiste Manneville, Ph.D.
Institut Curie

11:40 am - 12:00 pm EST
Probing the Role of Tissue Biophysics in Metastasis

Kandice Tanner, Ph.D.
Center for Cancer Research

12:00 pm - 12:20 pm EST
Mechanotransduction in Vivo: From Mesoderm Mechanotransductive Evolutionary Origins to Tumorigenic Mechanical Induction

Emmanuel Farge, Ph.D.
Institut Curie

12:20 pm - 12:40 pm EST
Splicing Factor Mutations and Cancer

Daniel Larson, Ph.D.
Center for Cancer Research

12:40 pm - 01:40 pm EST
LUNCH

Session 6:  Precision Prevention and Medicine

01:40 pm - 02:00 pm EST
Molecular Classification of Brain Tumors

Kenneth Aldape, M.D.
Center for Cancer Research

02:00 pm - 02:20 pm EST
Sherlock-Lung: Tracing Lung Cancer Mutational Processes in Never Smokers

Maria Teresa Landi, M.D., Ph.D.
Division of Cancer Epidemiology and Genetics

02:20 pm - 02:40 pm EST
Precision Medicine Strategies at Institut Curie

Christophe Le Tourneau, M.D., Ph.D.
Institut Curie

02:40 pm - 03:00 pm EST
Precision Therapy of Lymphoma Based on Genomic Insights into Disease Pathogenesis

Louis Staudt, Ph.D.
Center for Cancer Research

03:00 pm - 03:20 pm EST
Human Papillomavirus Genomic Insights into Cervical Carcinogenesis

Lisa Mirabello, Ph.D.
Division of Cancer Epidemiology & Genetics

03:20 pm - 03:40 pm EST
Deciphering the Biology of Thoracic Cancer: Frequent and Rare Tumors

Nicolas Girard, M.D.
Institut Curie

03:40 pm - 04:00 pm EST
New Quantitative Approaches to Precision Screening: The Example of Lung-Cancer Screening

Hormudz Katki, Ph.D.
Division of Cancer Epidemiology & Genetics

04:00 pm - 04:05 pm EST
Wrap-up and Adjourn