Thursday, April 11, 2019

09:00 am - 09:05 am
Welcome and Introductions

Sandra Wolin, M.D., Ph.D.
Center for Cancer Research, NCI

Session 1:  Non-Coding RNAs
                    Chair:  Joana Vidigal, Ph.D., Center for Cancer Research, NCI


09:05 am - 09:30 am
Messages from Long Non-coding RNAs

Ashish Lal, Ph.D.
Center for Cancer Research, NCI

09:30 am - 09:55 am
High-Throughput Strategies for Generating RNA Biosensors and Controllers

Christina Smolke, Ph.D
Stanford University

09:55 am - 10:20 am
MicroRNAs and Other Regulatory RNAs

David Bartel, Ph.D.
Massachusetts Institute of Technology

10:20 am - 10:45 am
Nuclear Non-coding RNAs: Mechanism and Therapy

David Corey, Ph.D.
UT Southwestern

10:45 am - 11:05 am

Session 2:  Prokaryotic RNAs
                    Chair:  Astrid Haase, M.D., Ph.D., NIDDK, NIH

11:05 am - 11:30 am
Value of Complexity and Redundancy in Regulatory RNA Networks

Gisela Storz, Ph.D.
National Institute of Child Health and Human Development, NIH

11:30 am - 11:55 am
CRISPR-Cas, Acquired Immunity in Prokaryotes

Luciano Marraffini, Ph.D.
Rockefeller University

11:55 am - 01:00 pm

Session 3:  RNA Modifications
                    Chair:  Pedro Batista, Ph.D., Center for Cancer Research, NCI

01:00 pm - 01:25 pm
The Regulatory Potential of RNA Modifications in Stem Cells

Michaela Frye, Ph.D.
University of Cambridge

01:25 pm - 01:50 pm
Acetylation of Cytidine in Messenger RNA Promotes Translation Efficiency

Shalini Oberdoerffer, Ph.D.
Center for Cancer Research, NCI

01:50 pm - 02:15 pm
The Dynamic Epitranscriptome: Control of mRNA Fate and Function with Reversible Nucleotide Modifications

Samie Jaffrey, M.D., Ph.D.
Weill Cornell Medical College

02:15 pm - 03:30 pm
Poster Session 1

Session 4:  RNA Binding Proteins
                    Chair:  Shuo Gu, Ph.D., Center for Cancer Research, NCI

03:30 pm - 03:55 pm
With a Little Help from My Friends: Cooperative Recognition of RNA by PUF Proteins and Company

Traci Hall, Ph.D.
National Institute of Environmental Health Sciences

03:55 pm - 04:55 pm
Keynote: Transcriptional Coactivator PGC-1α Contains a Novel CBP80-binding Motif That Orchestrates Efficient Target Gene Expression

Lynne Maquat, Ph.D.
University of Rochester

Friday, April 12, 2019

Session 5:  MRNA Processing 
                    Chair:  Stavroula Mili, Ph.D., Center for Cancer Research, NCI

09:15 am - 09:40 am
RNA Granules in Health and Disease

Roy Parker, Ph.D.
University of Colrado

09:40 am - 10:05 am
Regulation of mRNA Stability Through Codon and Amino Acid Identity

Jeffrey Coller, Ph.D.
Case Western Reserve University

10:05 am - 10:30 am

Session 6:  Circular RNAs
                    Chair:  Joseph Ziegelbauer, Ph.D., Center for Cancer Research, NCI

10:30 am - 10:55 am
Linking Circular RNA Biogenesis to Function

Lingling Chen, Ph.D.
Shanghai Institute of Biochemistry and Cell Biology

10:55 am - 11:20 am
circRNAs in Neuronal Development and Human Diseases

Jorgen Kjems, Ph.D.
Aarhus University

11:20 am - 11:45 am
Circular RNAs and Other Unexpected Outputs of Protein-Coding Genes

Jeremy Wilusz, Ph.D.
University of Pennsylvania

11:45 am - 01:00 pm

Session 7:  Structural Biology of Translation
                    Chair:  Jay Schneekloth, Jr., Ph.D., Center for Cancer Research, NCI

01:00 pm - 02:00 pm
Keynote: Cryo-EM and the Ribosome -- a Long, Happy Marriage

Joachim Frank, Ph.D.
Columbia University

02:00 pm - 03:15 pm
Poster Session 2

Session 8:  Synthetic Biology and Translational Applications
                    Chair:  Natasha Caplen, Ph.D. Center for Cancer Research, NCI
Chair:  Jack Shern, M.D., Center for Cancer Research, NCI

03:15 pm - 03:40 pm
Finding New Ways to Halt Breast Cancer Progression

David Spector, Ph.D.
Cold Spring Harbor

03:40 pm - 04:05 pm
Electrostatic Assembly and Polymeric Constructs for RNA Delivery

Paula Hammond, Ph.D.
Massachusetts Institute of Technology

04:05 pm - 04:30 pm
Designing RNA Agonists and Antagonists for RIG-I and Related Innate Immune Receptors

Anna Pyle, Ph.D.
Yale University

04:30 pm - 04:55 pm
Opportunities in using RNA Synthetic Biology for Cancer Immunotherapy and Vaccination

Ron Weiss, Ph.D.
Massachusetts Institute of Technology

04:55 pm - 05:00 pm
Closing Remarks & Adjourn