Agenda

Thursday, Oct 20 Friday, Oct 21

Thursday, October 20, 2022

09:15 am - 09:30 am EST
Welcome Remarks

Gordon L. Hager, Ph.D.
Chief
Laboratory of Receptor Biology and Gene Expression
Center for Cancer Research, NCI

Session 1:  Genome Organization and Function
                    Chair:  Gordon L. Hager, Center for Cancer Research, NCI

09:30 am - 10:00 am EST
Do EcDNAs Have Special Properties in the Nucleus That Drive Oncogene Expression in Cancer?

Wendy Bickmore, Ph.D.
University of Edinburgh

10:00 am - 10:30 am EST
Mechanisms Linking Gene Regulation and Chromosome Structure

 

Richard Young, Ph.D.
Whitehead Institute
Massachusetts Institute of Technology

10:30 am - 11:00 am EST
Multiplexed Imaging of Chromatin Marks and Gene Loci Links Cellular State to Gene Activity

Lucas Pelkmans, M.D., Ph.D.
University of Zurich

11:00 am - 11:30 am EST
Heterochromatin Repair Mechanisms

Irene Chiolo, Ph.D.
University of Southern California

11:30 am - 12:30 pm EST
Lunch

Session 2:  Mechanotransduction I
                    Chair:  David L. Levens, M.D., Ph.D., Center for Cancer Research, NCI

12:30 pm - 01:00 pm EST
Chromosome Position in Relation to the Centrosomes Determines Their Fate in Mitosis

Iva Tolić, Ph.D. 
Ruđer Bošković Institute

01:00 pm - 01:30 pm EST
Mechanics and Dynamics of Chromosomes and Cell Nuclei

 

John Marko, Ph.D.
Northwestern University

01:30 pm - 02:00 pm EST
Structural Changes in Chromosomes Driven by Multiple Condensin Motors During Mitosis

Dave Thirumalai, Ph.D.
University of Texas

02:00 pm - 02:30 pm EST
Differentiating Cells by Folding the Blueprints

Alistar Boettiger, Ph.D.
Stanford University

02:30 pm - 03:00 pm EST
Break

Session 3:  Mechanotransduction II
                    Chair:  Mirit I. Aladjem, Ph.D., Center for Cancer Research, NCI

03:00 pm - 03:30 pm EST
Enhancer-Promoter Interactions in Human Pancreas Cells

Efsun Arda, Ph.D.
Center for Cancer Research, NCI

03:30 pm - 04:00 pm EST
New Tricks from an Old Dog: Controlling Topoisomerase II Activity by Liquid Phase Condensation

James M. Berger, Ph.D.
Johns Hopkins University School of Medicine

04:00 pm - 04:30 pm EST
Nuclear Deformation Modulates Stem Cell Fate by Altering Chromatin Accessibility & Gene Expression

Yekaterina Miroshnikova, Ph.D.
National Institute of Diabetes and Digestive and Kidney Diseases, NIH

04:30 pm - 05:00 pm EST
Investigating the Mechanistic Basis of Inherited Susceptibility to Breast Cancer Metastasis

Kent Hunter, Ph.D.
Center for Cancer Research, NCI

Friday, October 21, 2022

Session 4:  Phase Separation and Condensates I
                    Chair:  Ashish Lal, Ph.D., Center for Cancer Research, NCI

09:30 am - 10:00 am EST
The RNA Code in Condensates

Amy Gladfelter, Ph.D.
University of North Carolina

10:00 am - 10:30 am EST
(Very) Complex Fluids: Why Nuclear Condensates are so Interesting

Clifford Brangwynne, Ph.D.
Princeton University

10:30 am - 11:00 am EST
mRNA-controlled Processes in Cytoplasmic Condensates

 

 

Christine Mayr, M.D., Ph.D.
Memorial Sloan Kettering Center Center

11:00 am - 11:30 am EST
Physical Principles of Protein and RNA Phase Separation

Rohit Pappu, Ph.D.
Washington University in St. Louis

11:30 am - 12:30 pm EST
Lunch

Session 5:  Phase Separation and Condensates II
                    Chair:  Michael Lichten, Ph.D., Center for Cancer Research, NCI

12:30 pm - 01:00 pm EST
Phase Separation, 3D Chromatin Structure and Cancer

 

Douglas Phanstiel, Ph.D.
University of North Carolina

01:00 pm - 01:30 pm EST
Mechanistic Analyses of the INO80 Chromatin Remodeling Complex

 

Geeta Narlikar, Ph.D.
University of California, San Francisco

01:30 pm - 02:00 pm EST
Self-assembly of Promoter DNA and RNA Polymerase II Machinery into Transcriptionally Active Biomolecular Condensates

Brian Lewis, Ph.D.
Center for Cancer Research, NCI

02:00 pm - 02:30 pm EST
The Synaptonemal Complex Is a Conduit for Diffusion and Patterning Between Meiotic Chromosomes

Abby Dernburg, Ph.D.
University of California, Berkeley

02:30 pm - 03:00 pm EST
Break

Session 6:  Phase Separation and Condensates III
                    Chair:  Shalini Oberdoerffer, Ph.D., Center for Cancer Research

03:00 pm - 03:30 pm EST
Nuclear Functions of Intermediate Filament Proteins and a Phase Separation Protein BuGZ

 

Yixian Zheng, Ph.D.
Carnegie Institute for Science

03:30 pm - 04:00 pm EST
AG02 Silences Mobile Transposons in the Nucleus of Quiescent Cells

Joana Vidigal, Ph.D.
Center for Cancer Research, NCI

04:00 pm - 04:30 pm EST
Transcription and Splicing Regulation by Kinetic Proofreading

Daniel Larson, Ph.D.
Center for Cancer Research, NCI

04:30 pm - 05:00 pm EST
Live Cell Single Molecule Imaging: Uncovering New Mechanisms and Disrupting Old Paradigms in Gene regulation

Robert Tjian, Ph.D.
University of California, Berkely