Agenda

The symposium will feature our keynote speaker, Dr. Ludmil Alexandrov, University of California, San Diego and several talks selected from submitted abstracts. 

Dr. Alexandrov is an Assistant Professor in the Department of Cellular and Molecular Medicine and the Department of Bioengineering at the University of California San Diego. He is am interested in disentangling the enigmatic secrets hidden in large omics datasets. Dr. Alexandrov's research is focused on developing novel machine-learning approaches and in leveraging these approaches to elucidate the basic molecular mechanism underlying cancer development and cancer progression. 

Friday, November 2, 2018

08:50 am - 09:00 am EST
Welcome Note and Introduction about the Center of Excellence in Integrative Cancer Biology and Genomics (CEICBG) symposiums
09:00 am - 09:20 am EST
Finding Driver Mutations in Cancer by Integrating Mutational Signatures into Models of Background Mutation Rate

Anna-leigh Brown, BSc | Computational Biology Branch, NCBI, NLM, NIH

 

09:20 am - 10:30 am EST
Keynote Address

The Repertoire of Mutational Signatures in Human Cancer

Ludmil Alexandrov, Ph.D.

Assistant Professor, Department of cellular and Molecular Medicine

University of California San Diego

10:30 am - 10:40 am EST
Break
10:40 am - 11:00 am EST
Hidden Markov Models Lead to Higher Resolution Maps of Mutational Signature Activity in Cancer

Teresa Przytycka, PhD | Computational Biology Branch, NCBI, NLM, NIH

11:00 am - 11:20 am EST
Combinations of Mutational Processes Define Molecular Subtypes in Heterogeneous Cancers

 Alexander Goncearenco, PhD | NCBI, NLM, NIH

11:20 am - 11:40 am EST
Correlation of Gene Expression and Associated Mutation Profiles of APOBEC3A, APOBEC3B, REV1, UNG, and FHIT with Chemosensitivity of Cancer Cell Lines to Drug Treatment

Suleyman Vural, PhD | Computational and Systems Biology Branch, Biometric Research Program, Division of Cancer Treatment and Diagnosis, NCI

11:40 am - 12:00 pm EST
Methods for Detecting Contribution of Mutational Signatures in Cancer Genomes

Damian Michal Wojtowicz, PhD | NCBI, NLM, NIH

12:00 pm - 12:20 pm EST
Functional characterization of the 14q24 renal cancer susceptibility locus implicates SWI/SNF complex member DPF3

Leandro M. Colli, MD, PhD | Laboratory of Genetic Susceptibility, CCR, NCI, NIH

12:20 pm - 12:40 pm EST
Metastatic Adrenocortical Carcinoma Displays Higher Mutation Rate and Tumor Heterogeneity than Primary Tumors

Sudheer Kumar Gara, PhD | Endocrine Oncology Branch, CCR, NCI, NIH

12:40 pm - 12:45 pm EST
Closing Remarks