Agenda

Monday, November 16, 2020

08:50 am - 09:00 am
Opening Remarks

John O'Shea, M.D.
Scientific Director, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH

Session 1:  Enhancer Genetics
Chair:  Ann Dean, Ph.D., National Institute of Diabetes and Digestive and Kidney Diseases, NIH

09:00 am - 09:05 am
Introduction

Francis Collins, M.D., Ph.D.
Director, National Institutes of Health

09:05 am - 09:30 am
Context-Specific Genetic Regulation of Chromatin Architecture in Diabetes

Stephen C.J. Parker, Ph.D.
University of Michigan

09:30 am - 10:00 am
Analysis of Promoter-Enhancer Interaction Using Hi-TrAC

Keji Zhao, Ph.D.
National Heart, Lung, and Blood Institute

10:00 am - 10:30 am
Nuclear Condensates Link Transcription to Cohesin Extrusion in Mammalian Cells

Rafael Casellas, Ph.D.
National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH

10:30 am - 10:45 am
BREAK
10:45 am - 11:15 am
Regulation of Gene Expression and Cell State by Cohesin

Jill Dowen, Ph.D.
University of North Carolina

11:15 am - 11:45 am
Context-Dependent Control of Enhancer Function

Denis Duboule, Ph.D.
Université de Genève

11:45 am - 12:15 pm
Enhancer-Promoter Conformations and Enhancer Function

Wendy Bickmore, Ph.D.
University of Edinburgh

12:15 pm - 01:15 pm
LUNCH

Session 2:  Enhancers in Development
Chair:  Todd Macfarlan, Ph.D., National Institute of Child Health and Human Development, NIH

01:15 pm - 01:45 pm
Post-mitotic Transcriptional and Architectural resetting of Pluripotent Stem Cell Identity

Effie Apostolou, Ph.D.
Weill Cornell Medicine

01:45 pm - 02:15 pm
Genome Regulation During Developmental Transitions: New Views of Old Questions

Eileen Furlong, Ph.D.
European Molecular Biology Laboratory

02:15 pm - 02:45 pm
Chromosome Topology and the Control of Enhancer-Promoter Interactions

Michael Levine, Ph.D.
Princeton University

02:45 pm - 03:15 pm
BREAK

Session 3:  Enhancer Biophysics
Chair: Daniel Larson, Ph.D., Center for Cancer Research, NCI

03:15 pm - 03:45 pm
Enhancer Communities Controlling Lineage Determination of Human Mesenchymal Stem Cells

Susanna Mandrup, Ph.D.
University of Southern Denmark

03:45 pm - 04:15 pm
Cell-Type Specialization in the Brain is Encoded by Specific Long-Range Chromatin Topologies

Ana Pombo, DPhil
Max Delbrück Center for Molecular Medicine

04:15 pm - 04:30 pm
Critical Binding Events and Causative Regulatory Variants Identified Using Deep Learning

Ivan Ovcharenko, Ph.D.
National Center for Biotechnology Information, NIH

04:30 pm - 05:00 pm
Chromosome Dynamics Near the Sol-Gel Phase Transition Dictate the Timing of Remote Genomic Interactions

Cornelis Murre, Ph.D.
University of California, San Diego

Tuesday, November 17, 2020

Session 4:  Enhancers in Disease
Chair:  Efsun Arda, Ph.D., Center for Cancer Research, NCI

09:00 am - 09:30 am
Enhancer-Promoter Looping, Gene Expression, and the Tale of an Unusual Transcription Factor

Gerd Blobel, M.D., Ph.D.
University of Pennsylvania

09:30 am - 10:00 am
Nuclear Condensates in Gene Regulation, Disease Pathology and Drug Partitioning

Richard Young, Ph.D.
Massachusetts Institute of Technology

10:00 am - 10:30 am
In Situ CAPTURE of Enhancer Structure-Function by Biotinylated dCas9

Jian Xu, Ph.D.
The University of Texas Southwestern Medical Center

10:30 am - 11:00 am
BREAK
11:00 am - 11:30 am
Regulatory Landscapes in the Evolution of Traits - the Genomic Origin of Intersexuality in Female Moles

Stefan Mundlos, M.D.
Max-Plank Institute

11:30 am - 11:45 am
Epigenomic Regulation of Lymphocyte Development and Activation

Han-yu Shih, Ph.D.
National Eye Institute, NIH

11:45 am - 12:15 pm
Mechanisms of Enhancer Activation Using the Histone Variant H3.3

Laura Banaszynski, Ph.D.
The University of Texas Southwestern Medical Center

12:15 pm - 01:15 pm
LUNCH

Session 5:  Enhancers and ncRNA
Chair:  Vittorio Sartorelli, M.D., National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH

01:15 pm - 01:45 pm
Impact of Non-Coding Genetic Variation on Signal-Dependent Gene Expression in Macrophages

Christopher Glass, M.D., Ph.D.
University of California, San Diego

01:45 pm - 02:15 pm
Enhancer RNAs are an Important Regulatory Layer of the Epigenome

Shannon Lauberth, Ph.D.
University of California, San Diego

02:15 pm - 02:45 pm
Integrator Complex Regulates the Coding and Noncoding Genome

Ramin Shiekhattar, Ph.D.
University of Miami Health System

02:45 pm - 03:00 pm
Wrap up and Adjourn