Agenda

                          Understanding & Drugging RAS --Are we there yet?

Tuesday, October 8

9:00 am – 9:50 am       Introduction & Welcome from 

                                     NCI Director—W. Kimryn Rathmell 

                                     NCI Principal Deputy Director—Douglas R. Lowy

                                     Remarks from Terri Conneran, founder of KRAS Kickers

                                     RAS Scientific Consultant—Frank McCormick

9:50 am - 12:10 pm     Session 1: RAS Therapeutics - Session Chair: Frank McCormick

                                      9:50 – 10:20    Mariano Barbacid, Spanish National Cancer Research Center

                                     10:20– 10:40   Andy Aguirre, Dana-Farber Cancer Institute

                                     10:40 – 11:00  Mallika Singh, Revolution Medicines

                                      11:00 – 11:20                 BREAK

                                      11:20 – 11:40  Robert Vonderheide, University of Pennsylvania

                                      11:40– 12:00   Ziyang Zhang, UC Berkeley

                                      11:55 – 12:10  Benjamin Huang, University of California, San Francisco — Short Talk (Abstract #53)                       

12:15 pm – 3:15 pm    Lunch/Poster Session

2:15 pm – 3:15 pm       Meet the Expert Sessions

3:15pm – 4:55 pm        Session 2: RAS Effectors - Session Chair: Andy Stephen

                                     3:15 – 3:35       Dhirendra Simanshu, Frederick National Laboratory for Cancer Research

                                     3:35 – 3:55       Pedro Beltran, Bridgebio Oncology Therapeutics               

                                     3:55 – 4:15                     BREAK

                                     4:15 – 4:35       Lucy Young, University of California, San Francisco          

                                     4:35 – 4:55       Debbie Morrison, National Cancer Institute 

                                     4:55 – 5:10       Jawahar Sudhamsu, Genentech – Short Talk (Abstract #102)

                                     5:10 – 5:25       Romain Baer, The Francis Crick Institute — Short Talk (Abstract #40)

Wednesday, October 9 

9:00 am – 9:30 am      Special Remarks from Margaret Foti – AACR CEO

9:30 am – 11:50 pm    Session 3: Biochemistry and Regulation of GTPases - Session Chair: Dom Esposito

                                    9:30 – 9:50       Andy Stephen, Frederick National Laboratory for Cancer Research       

                                    9:50 – 10:10     Brigitte Wideman — National Cancer Institute

                                   10:10 – 10:25    Sandra Misale, Johns Hopkins University School of Medicine — Short Talk (Abstract #46)

                                    10:25 – 10:55                 BREAK               

                                    10:55 – 11:15    Guillermo Calero, University of Pittsburgh School of Medicine 

                                    11:15 – 11:25     Alok Sharma, Frederick National Laboratory for Cancer Research —Short Talk (Abstract #100)

                                    11:25– 11:40      David Santamaria, Centro de Investigación del Cáncer — Short Talk (Abstract #37)

                                    11:40– 11:55      Rachel Lew, Ohio State University – Short Talk (Abstract #112)

11:55 pm – 2:45 pm    Lunch/Poster Session

2:00 pm – 2:45 pm       Meet the Expert Sessions

2:45 pm – 4:50 pm       Session 4: RAS and Entangled Pathways - Session Chair: Dhirendra Simanshu

                                     2:45 – 3:05       Greg Jones, Pfizer

                                     3:05 – 3:25       Channing Der, University of North Carolina 

                                     3:25 – 3:45       Xose Bustelo, Salamanca Cancer Research Center

                                      3:45 – 4:00                     BREAK

                                     4:00– 4:20        Pau Castel, NYU Langone Health 

                                     4:20 – 4:35       Daniel Bonsor, Frederick National Laboratory for Cancer Research — Short Talk (Abstract #127)

                                     4:35 – 4:50       Olesja Popow, Dana Farber Cancer Institute — Short Talk (Abstract #98)

4:50 pm – 5:50 pm       Session 5: RAS in Membranes - Session Chair: Tommy Turbyville

                                      4:50– 5:10        Moitrayee Bhattacharyya, Yale University

                                      5:10 – 5:30       Yong Zhou, University of Texas Health Science Center

                                      5:30 – 5:50       Gaudenz Danuser, UT Southwestern

5:50 pm – 8:00 pm      Networking Event, Rockwell Brewery (pre-paid, ticketed attendees only)

Thursday, October 10 

9:00 am – 11:10 am     Session 6:  Where are we and Next Steps - Session Chair: Dwight Nissley     

                                      9:00 am - 9:20  Piro Lito, Memorial Sloan Kettering Cancer Center 

                                     Panel Discussion: Optimal Strategy for Targeting KRAS for Clinical Benefit, moderated by Frank McCormick 

                                     9:20  – 10:20   Mallika Singh, Revolution Medicines; Cameron Pitt, Quanta Therapeutics; James Christensen, Mirati 

                                     Therapeutics

                                     10:20 – 10:35   Martin McMahon, University of Utah, Huntsman Cancer Institute — Short Talk (Abstract #3)

                                     10:35 – 10:50  Chad Pecot, EnFuego Therapeutics – Short Talk (Abstract #55)

                                     10:50 – 11:10   Kevan Shokat, University of California, San Francisco

11:10 am – 11:25 am  RAS Symposium Wrap Up and Highlights—Frank McCormick

        Pediatric Mini Symposium

11:30 am – 11:40 am  Pediatric Mini Symposium - Introduction - Christine Pratilas

11:45 am – 12:45 pm  Lunch & Networking

12:45 pm – 3:00 pm    Pediatrics RAS Session 1 

                                    12:45 - 12:50 Introduction - Elliot Stieglitz

                                    12:50 - 1:15  Meredith Irwin, The Hospital for Sick Children

                                    1:15 - 1:30    Angelina Vaseva, Oregon Health Science University - Short Talk (Abstract #P9)

                                    1:30 - 1:55    Sameer Agnihotri, UPMC Children’s Hospital of Pittsburgh

                                    1:55 - 2:10    Geoff Clark, James Graham Brown Cancer Center, University of Louisville - Short Talk (Abstract #P11)

                                    2:10 - 2:35    Carlos Prada, Lurie Children’s Hospital 

                                    2:35 - 3:00    BREAK

3:00 pm – 4:50 pm      Pediatrics RAS Session 2

                                    3:00 - 3:05   Introduction - Christine Pratilas

                                    3:05 - 3:30   Harrish Vasudevan, UCSF

                                    3:30 - 3:45   Patience Odeniyide, Johns Hopkins University School of Medicine - Short Talk (Abstract #P4)                                    

                                    3:45 - 4:10   Yana Pikman, Dana-Farber Cancer Institute

                                    4:10 - 4:25   Marielle Yohe, National Cancer Institute - Short Talk (Abstract #P7)                                    

                                    4:25 - 4:50   Elliot Stieglitz, UCSF Benioff Children’s Hospitals

4:50pm – 5:00 pm       Concluding Remarks, Mini-Symposium Wrap Up