Agenda

                                                                                               

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Objectives:

  • To share the latest progress on NCI-funded research related to the basic biological mechanisms and therapeutic targeting of fusion oncoproteins in childhood cancer. 
  • To exploit the synergy of this multi-disciplinary group to address shared challenges and advance common goals.

 

 

 

Wednesday, September 9, 2020

Chemistry for Targeting Fusions and Downstream Pathways

Moderator: Eric Fischer, Dana-Farber Cancer Institute

12:00 pm - 12:10 pm EST
Welcome and Quick Overview of Meeting Logistics

  Keren WitkinNational Cancer Institute

12:10 pm - 01:00 pm EST
Keynote Address: : Targeted protein degradation as a new therapeutic strategy

Nathanael Gray - Dana-Farber Cancer Institute

01:00 pm - 01:20 pm EST
Small molecule inhibitors directly targeting the EWS-FLI1 (ERG) fusion protein driver of Ewing’s sarcoma

John H. Bushweller University of Virginia School of Medicine

01:20 pm - 01:40 pm EST
Probing EWSR1-FLI1 function in Ewing sarcoma by inducible protein degradation

David McFaddenUT Southwestern

01:40 pm - 02:00 pm EST

Break 

02:00 pm - 02:20 pm EST
Phosphorylation and fibrolamellar hepatocellular carcinoma

Sanford SimonThe Rockefeller University

02:20 pm - 02:40 pm EST
Small molecule inhibitors targeting PAX3-FOXO1 oncoprotein activity in Rhabdomyosarcoma

Aykut Uren - Georgetown University

02:40 pm - 03:00 pm EST
GABA metabolism is a metabolic effector of fusion oncogene PAX-FKHR and contributes to Rhabdomyosarcoma malignancy

Siwen Kang - Nationwide Children's Hospital

03:00 pm - 03:45 pm EST

Group Discussion

Confidentiality Clause

The Annual Meeting for the Fusion Oncoproteins in Childhood Cancers (FusOnC2) Consortium may include confidential information as part of materials provided, presentations, and discussions. Confidential information presented at this meeting should not be disclosed outside of this Consortium and its invited guests, and care should be taken to maintain the confidentiality of all such information. Confidential information may include, but is not limited to, unpublished data, research results, theories, drawings and figures or visual depictions of research data or results regardless of format.

Thursday, September 10, 2020

 Phase Separation

Moderator: Richard Kriwacki, St. Jude Children's Research Hospital

12:00 pm - 12:40 pm EST
Liquid-liquid phase separation in cell physiology and disease

 Invited Speaker, Clifford Brangwynne Princeton University

12:40 pm - 01:00 pm EST
Fusions and hybrids: A role for phase separation in R-loop formation

Jacob C. SchwartzUniversity of Arizona

01:00 pm - 01:20 pm EST

Break

01:20 pm - 02:00 pm EST
Nuclear condensates in gene control, disease pathology and drug pharmacodynamics

Invited Speaker, Richard YoungWhitehead Institute/MIT

02:00 pm - 02:20 pm EST
The role of phase separation mediated by NUP98 fusion oncoproteins in leukemia

 Bappaditya ChandraSt. Jude Children's Research Hospital

 

02:20 pm - 02:40 pm EST
Ectopic nucleolar low-complexity domain interactions mislocalize nucleoplasmic EWS/FLI1 and suppress oncogenic transcription in Ewing’s Sarcoma

Shasha Chong University of California Berkeley

02:40 pm - 03:30 pm EST

Group Discussion 

Confidentiality Clause

The Annual Meeting for the Fusion Oncoproteins in Childhood Cancers (FusOnC2) Consortium may include confidential information as part of materials provided, presentations, and discussions. Confidential information presented at this meeting should not be disclosed outside of this Consortium and its invited guests, and care should be taken to maintain the confidentiality of all such information. Confidential information may include, but is not limited to, unpublished data, research results, theories, drawings and figures or visual depictions of research data or results regardless of format.

Friday, September 11, 2020

Chromatin Remodeling

Moderator: Cigall Kadoch, Dana-Farber Cancer Institute

12:00 pm - 12:20 pm EST
Chromatin remodeling maintains super-enhancer accessibility and represents a general tumor dependency

Beat W. SchäferUniversity Children's Hospital Zürich

12:20 pm - 12:40 pm EST
Understanding and targeting wild-type SS18 Function and Stability in Synovial Sarcoma

Marc Morgan - Northwestern University

12:40 pm - 01:00 pm EST
BAFs in synovial sarcoma: componentry and complex subtypes variation driven by SS18-SSX

Kevin Jones - Huntsman Cancer Institute/University of Utah

01:00 pm - 01:20 pm EST

Group Discussion 1

01:20 pm - 01:40 pm EST

Break  

01:40 pm - 02:00 pm EST
C11orf95 translocations constitute aberrant chromatin remodeling and transcription factors in ependymoma

Richard J. GilbertsonUniversity of Cambridge

02:00 pm - 02:20 pm EST
EWS/FLI-mediated reprogramming of the 3D chromatin landscape promotes an altered transcriptomic state in Ewing sarcoma

Iftekhar A. Showpnil Nationwide Children’s Hospital

02:20 pm - 02:40 pm EST
Genome-wide targeting of microsatellite repeat elements with engineered DNA binding domains

Miguel N. Rivera - Massachusetts General Hospital/ Dana-Farber Cancer Institute

02:40 pm - 03:00 pm EST

Group Discussion 2

03:00 pm - 03:45 pm EST
Consortium Discussion

Discussion Leader: Kimberly StegmaierDana-Farber Cancer Institute, FusOnC2 Steering Committee Chair

Confidentiality Clause

The Annual Meeting for the Fusion Oncoproteins in Childhood Cancers (FusOnC2) Consortium may include confidential information as part of materials provided, presentations, and discussions. Confidential information presented at this meeting should not be disclosed outside of this Consortium and its invited guests, and care should be taken to maintain the confidentiality of all such information. Confidential information may include, but is not limited to, unpublished data, research results, theories, drawings and figures or visual depictions of research data or results regardless of format.