Agenda

Please use this link to join the conference:  https://nci.rev.vbrick.com/#/webcasts/mousemodelsoflupus

Agenda

Thursday, December 10, 2020

08:30 am - 09:00 am EST
Opening Address

Hans-Joachim Anders: 10 reasons why "​This RCT failed to reproduce my beautiful mouse experiments”

SESSION 1
09:00 am - 09:20 am EST
Mark Shlomchik:

“Regulation of extrafollicular vs. conventional B cell responses in infection and autoimmunity”

09:20 am - 09:40 am EST
Jason Weinstein

“Transcriptional regulation of T follicular helper (Tfh) cells in murine and human lupus"

09:40 am - 10:00 am EST
Laurence Morel

“Using mouse models to understand the therapeutic value of metabolic inhibitors in lupus: making the case for metformin”

10:00 am - 10:20 am EST
J. Michelle Kahlenberg

“Understanding the UV response in lupus-prone skin”

SESSION 2
10:50 am - 11:10 am EST
Stefania Gallucci & Çagla Tükel

Stefania Gallucci: “Bacterial amyloids break tolerance in lupus”

Çagla Tükel: “Biofilm-associated Infections and autoimmunity”

11:10 am - 11:30 am EST
Gregg Silverman

"Murine models to evaluate a human pathobiont in Lupus Nephritis”

11:30 am - 11:50 am EST
Martin Kriegel & Daniel Zegarra-Ruiz

Martin Kriegel: “Lupus-prone animal models to identify human pathobionts in SLE”

Daniel Zegarra-Ruiz: “Gnotobiotic TLR7-driven lupus models for dietary interventions”

11:50 am - 12:10 pm EST
Xin Luo

“Gut Microbiota Regulation of Autoimmunity in the MRL/lpr Mouse Model”

SESSION 3: Targeting the T cell in lupus organ involvement: kidney and brain
01:00 pm - 01:20 pm EST
Chaim Putterman & Erica Moore

Chaim Putterman: “Blocking CD6/ALCAM interactions in lupus nephritis” 

Erica Moore: “TCR repertoire analysis in mouse and human NPSLE”

01:20 pm - 01:40 pm EST
Mariana Kaplan

“Targeting mitochondrial dysfunction in SLE”

01:40 pm - 02:00 pm EST
Anne Davidson & Tam Quach

Anne Davidson: “Circadian dysregulation in lupus nephritis”

Tam Quach: “Pathways to autoreactivity induced by TNF deficiency”

02:00 pm - 02:20 pm EST
Paul Hoover

“Deconstructing the myeloid compartment in lupus mouse models reveals novel cell states and gene programs shared with humans”

SESSION 4
02:50 pm - 03:10 pm EST
Deepak Rao

“T cell phenotypes and regulation across SLE patients and murine models”

03:10 pm - 03:30 pm EST
Betty Diamond

“Modelling cognitive impairment in NPSLE: from a models to a clinical trial”

03:30 pm - 03:50 pm EST
Eric Meffre

“Autoreactive B cell selection defects in humanized mice engrafted with HSCs from SLE patients”

03:50 pm - 04:10 pm EST
Jeremy Duffield

“Translating findings from murine models of SLE”

04:30 pm - 05:00 pm EST
Keynote Address

Eric Morand: “Connecting the dots - what does the interferon story teach us about translating from mouse to human in SLE?”