Agenda
Thursday, January 24, 2019
National Center for Advancing Translational Sciences (NCATS/NIH)
Accelerating Translation:
- Strategies for Rapid Probe Development
- Drug Combination Discovery and Precision Medicine.
Novel combinations
Developing Bacteriophage Cocktails to Target Resistant Isolates That Emerge During Treatment
Small molecule adjuvants in combination with antibiotics to overcome infections caused by multi-drug resistant bacteria
Break
Novel technologies
Small Molecule Targeting of Cellular and Viral RNAs
Phage-Mediated Molecular Detection of Staphylococcus aureus
Personalized Phage Therapy of a Lung Transplant Patient Infected with Antibiotic-Resistant Pseudomonas aeruginosa
Lunch
Evaluation of Post-exposure ZMappTM Infusion against Challenge with Aerosolized Ebola Virus
Novel targets or chemical classes
Leucine zipper-bearing kinase (LZK) is a novel therapeutic target in head and neck squamous cell carcinoma patients with 3q amplification
A small molecule inhibitor of MyD88 exhibits broad spectrum antiviral activity by upregulation of Type I Interferon
Break
TNIK, a novel druggable dependency in lung squamous cell carcinoma
Blockade of the cross-regulation of IFNg and IL-27 limits immunotherapy-induced immune-related adverse events in a murine model of systemic lupus erythematosus
Discovery of natural product modulators of Merkel Cell Carcinoma (MCC) cell viability
Concluding Remarks