Agenda

Agenda for NIH/FDA Glycoscience Research Day, August 28th 2024

8:45 a.m.   Introduction

Session I   Chair:  Florencia Haurat, FDA

Structure and Function of Glycans and their Biosynthetic Pathways

     9:00 a.m.   Anne Imberty, CNRS, Grenoble France (Zoom)
            “Lectins and Lectomes for Deciphering the Glycocode" 
     9:30 a.m.   Jochen Zimmer, UVA.
            “Molecular Insights into Hyaluronan Biosynthesis”   
   10:00 a.m.   Nadine Samara, NIDCR
            “A mucin-type O-glycosyltransferase from the protozoan pathogen Toxoplasma gondii is distinct from its host 

             homologues”

Coffee Break 10:30 - 10:50 am

Session II   Chair: Sebastian Temme

O-GlcNAc in Health and Disease. Chair, Sebastian Temme, NCI

     10:50 a.m., Charlie Fehl, Wayne State University.
            “Aberrant glycosylation patterns in hyperglycemic diseases: tools and targets”
     11:20 a.m., Amber Lockridge, NIDDK, 
            “A Fasting Fuel Switch to Fatty Acids is Facilitated by O-GlcNAc Removal”
     11:50 a.m., Priya Umapathi, Johns Hopkins.  
            “O-GlcNAc Biology in Action - Re-programming Cardiac Metabolism in Heart Failure”

Noon, Lunch & Networking and Poster Session12:20 - 2:30 pm

Authors at posters between 1-2:30 pm Natcher Atrium

Session III. Chair: Daron Freedberg, FDA

Glycobiology of Cancer
     
     2:30 p.m., Susan Bellis, U. Alabama.
           “Role of ST6GAL1 sialyltransferase in pancreatic cancer inititation and progression”      
     3:00 p.m., Tongzhaong Ju, FDA
           "Profound Regulation of EGFR Activation and Degradation through O-glycosylation"
     2:20 p.m.  Raja Mazumder, George Washigton University.
          "Pan-cancer analysis of genomic and glycosylation site-specific data in GlyGen"

Session IV.  Chair, Joe Barchi, NCI

Novel Glycan-Based Therapeutics and Glycomimetics 
     3:50 p.m., Jessica Stark, MIT.
           “Antibody-lectin chimeras for glyco-immune checkpoint blockade”      
     4:20 p.m., Avery Posey, University of Pennsylvania.
           "Chimeric antigen receptor T-cells targeting cancer-associated changes in glycosylation"
     4:50 p.m.  Umesh Desai, Virginia Commonwealth University.
          "Anticancer Mimetics of Sulfated Glycosaminoglycans"

Poster Awards and Concluding Remarks
     5:20 p.m., Presentation of Poster Awards
     5:30 p.m., Meeting Adjourns