RAS Initiative Symposium 2026
RAS Pathway 3.0 — Mechanisms, Resistance, and New Frontiers
October 7–9, 2026
Advanced Technology Research Facility, Frederick, MD
Day 1 – Wednesday, October 7
Opening Session and Welcome
Welcome and Meeting Logistics
Symposium Overview — Frank McCormick
Patient Advocate Perspective
Session 1: RAS Therapeutics and Resistance Mechanisms
Andy Aguirre
David Hong
Charlie Swanton
Mallika Singh
Karen Cichowski
Short Talk A
Lunch and Poster Session 1
Session 2: RAS Regulation and Biochemistry
Matt Sale
Xosé Bustelo
Short Talk B
Dhirendra Simanshu
Short Talk C
Short Talk: Introduction to the Proposed European RAS Initiative
Session Discussion
Day 2 – Thursday, October 8
Remarks from the NCI Director — Anthony Letai
Session 3: Prevention and Immunotherapy
Julian Downward
Tyler Jacks
Laura Wood
Short Talk A
Short Talk B
Session 4: Other Small GTPases and Pathway Crosstalk
Martin McMahon
Channing Der
Debbie Morrison
Short Talk C
Short Talk D
Lunch and Poster Session 2
European RAS Initiative Roundtable
Community Feedback on the Proposed European RAS Initiative
Vision and scope
Alignment with RAS Pathway 3.0 priorities
Opportunities for transatlantic collaboration
Session 5: Pathway Integration — Wild-Type vs Mutant RAS Signaling
Mariano Barbacid
David Tuveson
Allan Balmain
Short Talk E
Short Talk F
Discussion
Reception and Networking Event
Day 3 – Friday, October 9 (Half Day)
Session 6: Emerging Views and New Horizons in RAS Drug Discovery
Neeha Zaida
Piro Lito
Kevan Shokat
Short Talk A
Short Talk B
Closing Session: Future Directions and Integration
Summary from European RAS Initiative Roundtable
Future directions for RAS Pathway 3.0
Closing Remarks — Frank McCormick
12:15 PM — Adjourn