Tentative Agenda

Sixth RAS Initiative Symposium 2026

RAS Pathway 3.0 — Mechanisms, Resistance, and New Frontiers

Wednesday, October 7

Opening Session and Welcome (9:00 AM)

• Welcome and Meeting Logistics

• Symposium Overview — Frank McCormick

• Patient Advocate Perspective

Session 1: RAS Therapeutics and Resistance Mechanisms

9:40 – 10:05 — Andy Aguirre 

10:05 – 10:30 — David Hong 

10:30 – 10:55 — Charlie Swanton

10:55 – 11:10 — Coffee Break

11:10 – 11:35 — Mallika Singh 

11:35 – 12:00 — Karen Cichowski 

12:00 – 12:15 — Short Talk A 

Lunch and Poster Session 1 (12:15 – 2:30 PM)

Session 2: RAS Regulation and Biochemistry

2:30 – 2:55 — Matt Sale 
2:55 – 3:20 — Xosé Bustelo 
3:20 – 3:35 — Short Talk B
3:35 – 3:50 — Break
3:50 – 4:15 — Dhirendra Simanshu 
4:15 – 4:30 — Short Talk C 
4:30 – 4:45 — Short Talk: Introduction to the Proposed European RAS Initiative
4:45 – 5:15 — Session Discussion

Thursday, October 8

Session 3: Prevention and Immunotherapy 

9:00 – 9:10 — NCI Director - Anthony Letai

9:10 – 9:35 — Julian Downward

9:35 – 10:00 — Tyler Jacks

10:00 – 10:25 — Laura Wood

10:25 – 10:40 — Short Talk A

10:40 – 10:55 — Short Talk B

10:55 – 11:15 — Break

Session 4: Other Small GTPases and Pathway Crosstalk 

11:15 – 11:40 — Martin McMahon 

11:40 – 12:05 — Channing Der 

12:05 – 12:30 — Debbie Morrison 

12:30 – 12:45 — Short Talk C 

12:45 – 1:00 — Short Talk D 

Lunch and Poster Session 2 (1:00 – 3:00 PM)

European RAS Initiative Roundtable (2:30 – 3:15 PM)

• Community Feedback on the Proposed European RAS Initiative

• Vision and scope

• Alignment with RAS Pathway 3.0 priorities

• Opportunities for transatlantic collaboration

Session 5: Pathway Integration — Wild-Type vs Mutant RAS Signaling 

3:15 – 3:40 — Mariano Barbacid 

3:40 – 4:05 — David Tuveson 

4:05 – 4:30 — Allan Balmain 

4:30 – 4:45 — Short Talk E 

4:45 – 5:00 — Short Talk F

5:00 – 5:15 — Discussion

5:30 – 7:30 — Reception and Networking Event 

Friday, October 9 (Half Day)

Session 6: Emerging Views and New Horizons in RAS Drug Discovery 

9:00 – 9:25 — Neeha Zaida

9:25 – 9:50 — Piro Lito 

9:50 – 10:15 — Kevan Shokat 

10:15 – 10:30 — Short Talk A 

10:30 – 10:45 — Short Talk B 

10:45 – 11:00 — Break

Closing Session: Future Directions and Integration (11:00 AM)

• Summary from European RAS Initiative Roundtable

• Future directions for RAS Pathway 3.0

• Closing Remarks — Frank McCormick

12:15 PM — Adjourn