Anti-Human-GD3 MoAb (R24)

Antibody Specificity: Human GD3

Isotype: Murine IgG3

Process: Hybridoma fermentation (Celltech Limited). Clinical grade/Expired.

Concentration: 2.5 mg IgG/ml

Volume: 4 ml/vial

Amount Provided: 10 mg total

Buffer: Isotonic PBS plus human serum albumin (pH 5.9)

Product Testing:
MAP: Cell Line Negative Purity by HPLC: >90%
Mycoplasma: Cell Line Negative Sterility: Pass
Endotoxin: <1 EU/ml

Product Storage: -70oC

References:
 
1) Boussiotis VA, et.al. R24 anti-GD3 ganglioside antibody can induce costimulation and prevent the induction of alloantigen-specific T cell clonal anergy. Eur J Immunol 26:2149-2154, 1996
 
2) Houghton AN, et.al. Mouse Monoclonal IgG3 antibody detecting GD3 ganglioside: a phase I trial in patients with malignant melanoma. Proc Natl Acad Sci USA 82: 1242-1246, 1985
 
3) Welt S et.al. Immune and nonimmune effector functions of IgG3 mouse monoclonal antibody R24 detecting the disaloganglioside GD3 on the surface of melanoma cells. Clin Immunol Immnuopathol 45: 214-229, 1987
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Frederick, MD 21702-1201

BRBRepository@mail.nih.gov

For research use only. Not for drug or diagnostic use. NOT FOR USE IN HUMANS

Updated 11/6/2018