11B.11 MONOCLONAL ANTIBODY

Antibody Specificity: Mouse IL-4

Isotype: Rat IgG1

Buffer: 50mM Sodium Phosphate and 300mM Sodium Chloride, pH 6.

Lot Number: L0412006

Inventory Number: 05060201

Concentration: 21.2 mg/ml, 0.27 ml/vial (total 5.7 mg/vial)

Product Storage: -70oC

Product Testing:
MAP: Cell Line Negative Purity by HPLC: > 95%
Mycoplasma: Cell Line Negative Bioburden: 0 CFU/ml
Endotoxin: 1.54 EU/mg
Bioactivity:
In vitro: 0.9 ng/ml 11B.11 neutralizes 86.8% 500 pg/ml IL-4
9.0 ng/ml 11B.11 neutralizes 96.3% 500 pg/ml IL-4
90 ng/ml 11B.11 neutralizes >97% 500 pg/nl IL-4
In vivo: 5 mg of 11B.11 per week per mouse will significantly reduce endogenous IL-4 levels in most experimental situations.

Cell Line Origin: Dr. William Paul, NIH

References: Nature 315:33 (1985)

CAUTION: FOR RESEARCH USE ONLY. NOT FOR DRUG OR DIAGNOSTIC USE. NOT FOR USE IN HUMANS.

11B.11 is available to investigators with peer-reviewed support, at institutions, and at commercial establishments. Use of these materials is limited solely to in vivo and in vitro basic research studies.

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