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Uteroglobin is essential in preventing immunoglobulin A nephropathy in mice

  1. Author:
    Zheng, F.
    Kundu, G. C.
    Zhang, Z. J.
    Ward, J.
    Demayo, F.
    Mukherjee, A. B.

  2. Author Address

    Mukherjee AB NICHHD, Sect Dev Genet, Heritable Disorders Branch, NIH Bethesda, MD 20892 USA NICHHD, Sect Dev Genet, Heritable Disorders Branch, NIH Bethesda, MD 20892 USA NCI, Vet & Tumor Pathol Sect Frederick, MD 21702 USA Baylor Coll Med, Dept Cell Biol Houston, TX 77030 USA
    1. Year: 1999
  2. Journal: Nature Medicine
    1. 5
    2. 9
    3. Pages: 1018-1025
  4. Type of Article: Article
  1. Abstract:

    The molecular mechanism(s) of immunoglobulin A (IgA) nephropathy, the most common primary renal glomerular disease worldwide, is unknown. Its pathologic features include hematuria, high levels of circulating IgA-fibronectin (Fn) complexes, and glomerular deposition of IgA, complement C3, Fn and collagen. We report here that two independent mouse models (gene knockout and antisense transgenic), both manifesting deficiency of an anti-inflammatory protein, uteroglobin (UG), develop almost all of the pathologic features of human IgA nephropathy. We further demonstrate that Fn-UG heteromerization, reported to prevent abnormal glomerular deposition of Fn and collagen, also abrogates both the formation of IgA-Fn complexes and their binding to glomerular cells. Moreover, UG prevents glomerular accumulation of exogenous IgA in UG-null mice. These results define an essential role for UG in preventing mouse IgA nephropathy and warrant further studies to determine if a similar mechanism(s) underlies the human disease. [References: 42]

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