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The potentials of short fragments of human anti-microbial peptide LL-37 as a novel therapeutic modality for diseases

  1. Author:
    Chen,Keqiang
    Gong, Wanghua
    Huang,Jiaqiang
    Yoshimura, Teizo
    Wang,Jiming

  2. Author Address

    Laboratory of Cancer ImmunoMetabolism, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, MD 21702, USA., Basic Research Program, Leidos Biomedical Research, Inc., Frederick, MD 21702, USA., College of Life Sciences, Beijing Jiaotong University, 100044 Beijing, China., Department of Pathology and Experimental Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 700-8558 Okayama, Japan.,
    1. Year: 2021
    2. Date: Nov 30
  2. Journal: Frontiers in Bioscience - Landmark
    1. 26
    2. 11
    3. Pages: 1362-1372
  4. Type of Article: Article
  5. ISSN: 2768-6698
  1. Abstract:

    Human cathelicidin antimicrobial peptide LL-37 (LL-37) is an antimicrobial peptide derived from its precursor protein hCAP18, which is an only cathelicidin in human. LL-37 not only serves as a mediator of innate immune defense against invading microorganisms, but it also plays an essential role in tissue homeostasis, regenerative processes, regulation of proinflammatory responses, and inhibition of cancer progression. Therefore, LL-37 has been considered as a drug lead for diseases. However, high levels of LL-37 may reduce cell viability and promote apoptosis of osteoblasts, vascular smooth muscle cells, periodontal ligament cells, neutrophils, airway epithelial cells and T cells. Recent evidence reveals that LL-37-derived short peptides possess similar biological activities as the whole LL-37 with reduced cytotoxicity. Thus, such small molecules constitute a pool of potential therapeutic agents for diseases. © 2021 The Author(s). Published by BRI.

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External Sources

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  2. DOI: 10.52586/5029
  3. PMID: 34856773
  4. PII : s2768-6701(21)00084-8

Library Notes

  1. Open Access Publication
  2. Fiscal Year: FY2021-2022
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