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A New Bispyrroloiminoquinone Alkaloid From a Thai Collection of Clavelina sp.

  1. Author:
    Grkovic,Tanja
    Ruchirawat, Somsak
    Kittakoop, Prasat
    Grothaus,Paul
    Evans,Jason
    Britt, John R.
    Newman,Dave
    Mahidol, Chulabhorn
    O'Keefe,Barry

  2. Author Address

    NCI, Nat Prod Branch, Dev Therapeut Program, Div Canc Treatment & Diag, Frederick, MD 21702 USA.NCI, Mol Targets Program, Ctr Canc Res, Frederick, MD 21702 USA.Chulabhorn Res Inst, Lab Nat Prod, Kamphang Phet 6 Rd, Bangkok 10210, Thailand.Chulabhorn Grad Inst, Chem Biol Program, Kamphang Phet 6 Rd, Bangkok 10210, Thailand.CHE Minist Educ, Ctr Excellence Environm Hlth & Technol, Bangkok, Thailand.Frederick Natl Lab Canc Res, Nat Prod Support Grp, Frederick, MD 21702 USA.
    1. Year: 2021
    2. Date: Jul 21
  2. Journal: Asian Journal of Organic Chemistry
  3. Wiley-V C H Verlag GMBH,
    1. 10
    2. 7
    3. Pages: 1647-1649
  5. Type of Article: Article
  6. ISSN: 2193-5807
  1. Abstract:

    Two bispyrroloiminoquinone alkaloids, wakayin (1) and a new natural product 16-hydroxy-17-oxindole wakayin (2), were isolated from a Thai collection of the ascidian Clavelina sp. Herein, we present the isolation and structural elucidation of the new natural product and compare its NCI-60 cytotoxic activity to the known analogue wakayin and a series of other related pyrroloiminoquinones.

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External Sources

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  2. DOI: 10.1002/ajoc.202100155
  3. View record in Web of Science®
  4. WOS: 000641730800001

Library Notes

  1. Fiscal Year: FY2020-2021
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