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MR lymphangiography using dendrimer-based contrast agents: A comparison at 1.5T and 3.0T

  1. Author:
    Hama, Y.
    Bernardo, M.
    Regino, C. A. S.
    Koyama, Y.
    Brechbiel, M. W.
    Krishna, M. C.
    Choyke, P. L.
    Kobayashi, H.

  2. Author Address

    NCI, Mol Imaging Program, Ctr Canc Res, NIH, Bethesda, MD 20892 USA. NCI, Radiat Oncol Branch, NIH, Bethesda, MD 20892 USA. NCI, Radiat Biol Branch, NIH, Bethesda, MD 20892 USA. NCI, SAIC Frederick Inc, Frederick, MD 21701 USA.;Kobayashi, H, NCI, Mol Imaging Program, Ctr Canc Res, NIH, Bldg 10,Room 1B40,9000 Rockville Pike, Bethesda, MD 20892 USA.;Kobayash@mail.nih.gov
    1. Year: 2007
    2. Date: Feb
  2. Journal: Magnetic Resonance in Medicine
    1. 57
    2. 2
    3. Pages: 431-436
  4. Type of Article: Article
  5. ISSN: 0740-3194
  1. Abstract:

    Most macromolecular contrast agents (CAs) show lower r(1) and higher r(2) relaxivities at 3.0T than at 1.5T. MR lymphangiography in mice using a macromolecular G6 dendrimer-based CA was serially performed and compared at both 1.5T and 3.0T. The r(1) and r(2) relaxivities of the G6 CA were 25 and 78/s/mM at 1.5T and 17 and 82/s/mM at 3.0T, respectively. The lymph node (LN)-to-fat ratios (LN signal intensity (SI)/fat SI) of T-1-weighted 3D-fast spoiled gradient-echo (3D-FSPGR) were 3.2 +/- 0.4 (mean standard deviation (SD)) at 1.5T and 2.7 +/- 0.3 at 3.0T (P = 0.021), and the LN-to-fat ratios of T-2/T-1-weighted 3D-fast imaging employing steady-state acquisition with phase cycling (3D-FIESTA-C) were 1.8 +/- 0.2 at 1.5T and 1.2 +/- 0.4 at 3.0T (P = 0.003). Although 3D-FSPGR successfully delineated the LNs at both 1.5T and 3.0T, 3D-FIESTA-C at 3.0T failed to visualize the LNs.

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  2. DOI: 10.1002/mrm.21126
  3. View record in Web of Science®
  4. WOS: 000243946300024

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