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MYH9 is associated with nondiabetic end-stage renal disease in African Americans

  1. Author:
    Kao, W.
    Klag, M. J.
    Meoni, L. A.
    Reich, D.
    Berthier-Schaad, Y.
    Li, M.
    Coresh, J.
    Patterson, N.
    Tandon, A.
    Powe, N. R.
    Fink, N. E.
    Sadler, J. H.
    Weir, M. R.
    Abboud, H. E.
    Adler, S. G.
    Divers, J.
    Iyengar, S. K.
    Freedman, B. I.
    Kimmel, P. L.
    Knowler, W. C.
    Kohn, O. F.
    Kramp, K.
    Leehey, D. J.
    Nicholas, S. B.
    Pahl, M. V.
    Schelling, J. R.
    Sedor, J. R.
    Thornley-Brown, D.
    Winkler, C. A.
    Smith, M. W.
    Parekh, R. S.
    Family Investigation of Nephropathy and Diabetes Research Group

  2. Author Address

    Kao, W. H. Linda, Klag, Michael J.; Berthier-Schaad, Yvette, Li, Man, Coresh, Josef, Powe, Neil R.; Fink, Nancy E.; Parekh, Rulan S.] Johns Hopkins Univ, Dept Epidemiol, Baltimore, MD 21287 USA. [Kao, W. H. Linda, Klag, Michael J.; Meoni, Lucy A.; Powe, Neil R.; Fink, Nancy E.; Parekh, Rulan S.] Johns Hopkins Univ, Dept Med, Baltimore, MD 21287 USA. [Kao, W. H. Linda, Klag, Michael J.; Meoni, Lucy A.; Coresh, Josef, Powe, Neil R.; Fink, Nancy E.; Parekh, Rulan S.] Johns Hopkins Univ, Welch Ctr Prevent Epidemiol & Clin Res, Baltimore, MD 21287 USA. [Meoni, Lucy A.; Coresh, Josef] Johns Hopkins Univ, Dept Biostat, Sch Med, Baltimore, MD 21287 USA. [Meoni, Lucy A.; Coresh, Josef] Johns Hopkins Univ, Dept Biostat, Bloomberg Sch Publ Hlth, Baltimore, MD 21287 USA. [Reich, David, Tandon, Arti] Harvard Univ, Sch Med, Dept Genet, Boston, MA 02115 USA. [Reich, David, Patterson, Nick, Tandon, Arti] Harvard Univ, Broad Inst, Cambridge, MA 02142 USA. [Reich, David, Patterson, Nick, Tandon, Arti] MIT, Cambridge, MA 02142 USA. [Sadler, John H.; Weir, Matthew R.] Univ Maryland, Dept Med, Baltimore, MD 21201 USA. [Abboud, Hanna E.] Univ Texas Hlth Sci Ctr San Antonio, Dept Med, San Antonio, TX 78229 USA. [Adler, Sharon G.] Harbor UCLA Med Ctr, Los Angeles Biomed Res Inst, Dept Med, Los Angeles, CA 90502 USA. [Divers, Jasmin, Freedman, Barry I.] Wake Forest Univ, Bowman Gray Sch Med, Dept Med, Winston Salem, NC 27157 USA. [Iyengar, Sudha K.; Kramp, Kristopher] Case Western Reserve Univ, Sch Med, Dept Epidemiol & Biostat, Cleveland, OH 44109 USA. [Kimmel, Paul L.] NIDDK, NIH, Bethesda, MD 20892 USA. [Knowler, William C.] NIDDK, Diabet Epidemiol & Clin Res Sect, NIH, Phoenix, AZ 85014 USA. [Kohn, Orly F.] Loyola Univ, Dept Med, Chicago, IL 60153 USA. [Leehey, David J.] Univ Chicago, Dept Med, Chicago, IL 60637 USA. [Nicholas, Susanne B.] Univ Calif Los Angeles, David Geffen Sch Med, Dept Med, Los Angeles, CA 90024 USA. [Pahl, Madeleine V.] Univ Calif Irvine, Dept Med, Irvine, CA 92868 USA. [Schelling, Jeffrey R.; Sedor, John R.] Case Western Reserve Univ, Sch Med, Dept Med, Cleveland, OH 44109 USA. [Sedor, John R.] Case Western Reserve Univ, Sch Med, Dept Biophysiol & Biophys, Cleveland, OH 44109 USA. [Thornley-Brown, Denyse] Univ Alabama, Dept Med, Birmingham, AL 35294 USA. [Winkler, Cheryl A.; Smith, Michael W.] NCI, Lab Genom Divers, SAIC Frederick Inc, Frederick, MD 21702 USA. [Parekh, Rulan S.] Johns Hopkins Univ, Sch Med, Dept Pediat, Baltimore, MD 21287 USA.
    1. Year: 2008
  2. Journal: Nature Genetics
    1. 40
    2. 10
    3. Pages: 1185-1192
  4. Type of Article: Article
  1. Abstract:

    As end-stage renal disease (ESRD) has a four times higher incidence in African Americans compared to European Americans, we hypothesized that susceptibility alleles for ESRD have a higher frequency in the West African than the European gene pool. We carried out a genome-wide admixture scan in 1,372 ESRD cases and 806 controls and found a highly significant association between excess African ancestry and nondiabetic ESRD (lod score = 5.70) but not diabetic ESRD (lod = 0.47) on chromosome 22q12. Each copy of the European ancestral allele conferred a relative risk of 0.50 (95% CI = 0.39-0.63) compared to African ancestry. Multiple common SNPs (allele frequencies ranging from 0.2 to 0.6) in the gene encoding nonmuscle myosin heavy chain type II isoform A (MYH9) were associated with two to four times greater risk of nondiabetic ESRD and accounted for a large proportion of the excess risk of ESRD observed in African compared to European Americans.

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  2. DOI: 10.1038/ng.232
  3. PMID: 18794854
  4. PMCID: PMC2614692

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