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Naamidine A reveals a promising zinc-binding strategy for topical antifungal therapy

  1. Author:
    Puumala, Emily [ORCID]
    Nabeela, Sunna
    Thornburg,Chris
    Grkovic,Tanja
    Uppuluri, Priya [ORCID]
    Whitesell, Luke
    O'Keefe,Barry
    Robbins, Nicole
    Cowen, Leah E [ORCID]

  2. Author Address

    Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada., Division of Infectious Diseases, The Lundquist Institute for Biomedical Innovation at Harbor-University of California Los Angeles Medical Center, Torrance, California, USA., Natural Products Support Group, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA., Natural Products Branch, Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Frederick, Maryland, USA., Molecular Targets Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland, USA., David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA.,
    1. Year: 2024
    2. Date: Sep 26
    3. Epub Date: 2024 09 26
  2. Journal: Antimicrobial Agents and Chemotherapy
    1. Pages: e0119424
  4. Type of Article: Article
  5. Article Number: e0119424
  1. Abstract:

    Fungal disease affects over a billion people worldwide. Naamidine A inhibits the growth of diverse fungal pathogens through an unknown mechanism. Here, we show that the supplementation of medium with excess zinc abolishes the antifungal activity of naamidine A. Furthermore, we highlight that naamidine A has in vitro activity against terbinafine-resistant Trichophyton spp. and in vivo efficacy in a mouse model of dermatomycosis caused by T. mentagrophytes, highlighting its therapeutic potential as a topical treatment.

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External Sources

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  2. DOI: 10.1128/aac.01194-24
  3. PMID: 39324798

Library Notes

  1. Fiscal Year: FY2024-2025
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