Skip NavigationSkip to Content
Return Return to Search Results

The role of cytokines in lymphocyte homeostasis

  1. Author:
    Khaled, A. R.
    Durum, S. K.

  2. Author Address

    NCI, Sect Cytokines & Immun, Mol Immunoregulat Lab, Ctr Canc Res, Bldg 560,Rm 31-71, Frederick, MD 21702 USA NCI, Sect Cytokines & Immun, Mol Immunoregulat Lab, Ctr Canc Res, Frederick, MD 21702 USA Durum SK NCI, Sect Cytokines & Immun, Mol Immunoregulat Lab, Ctr Canc Res, Bldg 560,Rm 31-71, Frederick, MD 21702 USA
    1. Year: 2002
  2. Journal: Biotechniques
    1. Suppl. S
    2. Pages: 40-45
  4. Type of Article: Review
  1. Abstract:

    The size of lymphocyte populations is regulated by replication and death. Cytokines produced by non-lymphoid cells provide key survival and replication signals for several lymphocyte subpopulations. The availability of these cytokines thus serves as a homeostatic regulatory mechanism by determining the upper limit of the population size. IL-7 is required for survival of naive CD4(+) and CD8(+) cells and memory CD8(+) cells. IL-15 is required for survival of memory CD8(+) cells. IL-12 and IL-4 also promote memory CD8(+) survival BAFF is required for survival of mature B cells. Antigen receptor signals, together with these cytokines signals, are required for survival of mature B cells and naive T cells. The list of extracellular survival signals for lymphocytes remains incomplete, and the intracellular pathways leading to survival are poorly understood.

    See More

  1. Keywords:

External Sources

  1. No sources found.

Library Notes

  1. No notes added.
NCI at Frederick

You are leaving a government website.

This external link provides additional information that is consistent with the intended purpose of this site. The government cannot attest to the accuracy of a non-federal site.

Linking to a non-federal site does not constitute an endorsement by this institution or any of its employees of the sponsors or the information and products presented on the site. You will be subject to the destination site's privacy policy when you follow the link.

ContinueCancel