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Alarmins initiate host Defense

  1. Author:
    Oppenheim, J. J.
    Tewary, P.
    de la Rosa, G.
    Yang, D.

  2. Author Address

    NCI, Lab Mol Immunoregulat, Canc Res Ctr, Frederick, MD 21701 USA. SAIC Frederick Inc, Basic Res Program, Frederick, MD USA.;Oppenheim, JJ, NCI, Lab Mol Immunoregulat, Canc Res Ctr, Frederick, MD 21701 USA.;Oppenhei@ncifcrf.gov
    1. Year: 2007
  2. Book Title: Immune-Mediated Diseases: From Theory to Therapy
  3. Series Title: Advances in Experimental Medicine and Biology
  4. Springer-Verlag Berlin
  5. Berlin
    1. 601
    2. Pages: 185-194
  7. Type of Work: Book Chapter
  8. ISBN: 0065-2598
  1. Abstract:

    In response to infection and/or tissue injury, cells of the host innate immune system rapidly produce a variety of structurally distinct mediators (we elect to call alarmins) that not only function as potent effectors of innate defense but also act to alarm the immune system by promoting the recruitment and activation of host leukocytes through interaction with distinct receptors. Alarmins are capable of activating antigen-presenting cells (APCs) and enhancing the development of antigen-specific immune responses. Here, we discuss the characteristics of several alarmins, a variety of potential alarmin candidates and potential implications of alarmins.

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External Sources

  1. View record in Web of Science®
  2. WOS: 000248597900019

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