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Structural studies of series HIV-1 nonnucleoside reverse transcriptase inhibitors 1-(2,6-difluorobenzyl)-2-(2,6-difluorophenyl)-benzimidazoles with different 4-substituents

  1. Author:
    Ziolkowska, N. E.
    Michejda, C. J.
    Bujacz, G. D.

  2. Author Address

    [Ziolkowska, Natasza E.; Bujacz, Grzegorz D.] Tech Univ Lodz, Inst Tech Biochem, PL-90924 Lodz, Poland. [Michejda, Christopher J.] NCI, Mol Aspects Drug Design Sect, Frederick, MD 21702 USA.;Bujacz, GD, Max Planck Inst Biochem, Klopferspitz 18, D-82152 Martinsried, Germany.;gdbujacz@p.lodz.pl
    1. Year: 2010
    2. Date: Mar
  2. Journal: Journal of Molecular Structure
    1. 966
    2. 1-3
    3. Pages: 53-58
  4. Type of Article: Article
  5. ISSN: 0022-2860
  1. Abstract:

    Over the past 10 years, several anti-viral drugs have become available to fight the HIV infection. Antiretroviral treatment reduces the mortality of AIDS. Nonnucleoside inhibitors of HIV-1 reverse transcriptase are specific and potentially nontoxic drugs against AIDS. The crystal structures of five nonnucleoside inhibitors of HIV-1 reverse transcriptase are presented here. The structural parameters, especially those describing the angular orientation of the pi-electron systems and influencing biological activity, were determined for all of the investigated inhibitors. The chemical character and orientation of the substituent at C4 position of the benzimidazole moiety substantially influences the anti-viral activity. The structural data of the investigated inhibitors is a good basis for modeling enzyme-inhibitor interactions for structure-assisted drug design. (C) 2009 Elsevier B.V. All rights reserved.

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External Sources

  1. View Full Text
  2. DOI: 10.1016/j.molstruc.2009.12.006
  3. View record in Web of Science®
  4. WOS: 000275769700009

Library Notes

  1. Fiscal Year: FY2009-2010
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