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Multivalent dendrimeric compounds containing carbohydrates expressed on immune cells inhibit infection by primary isolates of HIV-1

  1. Author:
    Borges, A. R.
    Wieczorek, L.
    Johnson, B.
    Benesi, A. J.
    Brown, B. K.
    Kensinger, R. D.
    Krebs, F. C.
    Wigdahl, B.
    Blumenthal, R.
    Puri, A.
    McCutchan, F. E.
    Birx, D. L.
    Polonis, V. R.
    Schengrund, C. L.

  2. Author Address

    [Borges, Andrew Rosa; Wieczorek, Lindsay; Brown, Bruce K.; McCutchan, Francine E.] Henry M Jackson Fdn, Mil HIV Res Program, Rockville, MD 20850 USA. [Johnson, Benitra; Blumenthal, Robert; Puri, Anu] NCI, Ctr Canc Res, NIH, Frederick, MD 21701 USA. [Benesi, Alan J.] Penn State Univ, Dept Chem, State Coll, PA USA. [Kensinger, Richard D.; Schengrund, Cara-Lynne] Penn State Univ, Coll Med, Dept Biochem & Mol Biol, Hershey, PA USA. [Krebs, Fred C.; Wigdahl, Brian] Drexel Univ, Coll Med, Dept Microbiol & Immunol, Philadelphia, PA 19104 USA. [Birx, Deborah L.; Polonis, Victoria R.] Walter Reed Army Inst Res, Mil HIV Res Program, Div Retrovirol, Rockville, MD USA.;Schengrund, CL, Penn State Coll Med, Dept Biochem & Mol Biol, 500 Univ Dr, Hershey, PA 17033 USA.;cxs8@psu.edu
    1. Year: 2010
    2. Date: Dec
  2. Journal: Virology
    1. 408
    2. 1
    3. Pages: 80-88
  4. Type of Article: Article
  5. ISSN: 0042-6822
  1. Abstract:

    Specific glycosphingolipids (GSL), found on the surface of target immune cells, are recognized as alternate cell surface receptors by the human immunodeficiency virus type 1 (HIV-1) external envelope glycoprotein. In this study, the globotriose and 3'-sialyllactose carbohydrate head groups found on two GSL were covalently attached to a dendrimer core to produce two types of unique multivalent carbohydrates (MVC). These MVC inhibited HIV-1 infection of T cell lines and primary peripheral blood mononuclear cells (PBMC) by T cell line-adapted viruses or primary isolates, with IC(50)s ranging from 0.1 to 7.4 mu g/ml. Inhibition of Env-mediated membrane fusion by MVC was also observed using a dye-transfer assay. These carbohydrate compounds warrant further investigation as a potential new class of HIV-1 entry inhibitors. The data presented also shed light on the role of carbohydrate moieties in HIV-1 virus-host cell interactions. (C) 2010 Elsevier Inc. All rights reserved.

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External Sources

  1. View Full Text
  2. DOI: 10.1016/j.virol.2010.09.004
  3. View record in Web of Science®
  4. WOS: 000283970500009

Library Notes

  1. Fiscal Year: FY2010-2011
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