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Socio-Economic and Other Correlates of Kaposi Sarcoma-Associated Herpesvirus Seroprevalence Among Older Adults in Sicily

  1. Author:
    Pelser, C.
    Vitale, F.
    Whitby, D.
    Graubard, B. I.
    Messina, A.
    Gafa, L.
    Brown, E. E.
    Anderson, L. A.
    Romano, N.
    Lauria, C.
    Goedert, J. J.

  2. Author Address

    Goedert, James J.] NCI, Infect & Immunoepidemiol Branch, Div Canc Epidemiol & Genet, NIH, Rockville, MD 20892 USA. [Pelser, Colleen] Univ Maryland, Sch Med, Dept Epidemiol & Prevent Med, Baltimore, MD 21201 USA. [Vitale, Francesco] Univ Palermo, Dept Sci Hlth Promot G Alessandro, Sect Hyg, Palermo, Italy. [Whitby, Denise] NCI, Viral Oncol Sect, AIDS & Canc Virus Program, SAIC Frederick, Frederick, MD 21701 USA. [Messina, Angelo] Univ Catania, Dipartimento Sci Biomed, Catania, Italy. [Gafa, Lorenzo, Lauria, Carmela] Lega Italiana Lotta Contro & Tumori Sez Ragusa, Ragusa, Italy. [Brown, Elizabeth E.] Univ Alabama, Dept Epidemiol Med & Microbiol, Birmingham, AL USA. [Anderson, Lesley A.] Queens Univ Belfast, Ctr Publ Hlth, Belfast, Antrim, North Ireland.
    1. Year: 2009
  2. Journal: Journal of Medical Virology
    1. 81
    2. 11
    3. Pages: 1938-1944
  4. Type of Article: Article
  1. Abstract:

    The virus that causes Kaposi sarcoma, KS-associated herpesvirus (KSHV, also known as human herpesvirus 8) has an unusual distribution and poorly characterized modes of transmission. To clarify these issues, socio-demographic correlates of KSHV seroprevalence were examined in a population-based study. In 1,154 randomly sampled adults (aged 3292, mean 71 years) throughout Sicily, KSHV antibodies were detected with four assays and a conservative algorithm. Seroprevalence was re-weighted to the population. Odds ratios with 95% confidence intervals (OR, CI) from multivariate logistic regression were used to estimate associations of seroprevalence with interview data. KSHV seroprevalence was 8.5%, including 5.3% among men (N=848) and 11.5% among women (N=306, P=0.22). Seroprevalence was higher with residence in a smaller community during childhood (P-trend=0.03) and working with plants/soil during adulthood (OR 2.9, CI 1.1-7.9); these were especially strong among women. Among men, seroprevalence was significantly associated with lower education (OR 2.6, CI 1.1-5.9) and migration to a larger community (OR 0.3, CI 0.1-0.9). Other demographic and household variables were unrelated to seroprevalence. From these data, KSHV in Sicily appears to be related to low socio-economic status, but micro-endemicity in small communities cannot be excluded. J. Med. Virol. 81:1938-1944, 2009. (C) 2009 Wiley-Liss, Inc.(+)

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  2. DOI: 10.1002/jmv.21589
  3. PMID: 19777527

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