Platinum Publications are selected from articles by NCI at Frederick scientists published in 42 prestigious science journals. This list represents articles published during the time period shown above, as generated from PubMed.
Articles designated as Platinum Highlights are noteworthy articles selected by Dr. Craig Reynolds, associate director, National Cancer Institute, from among the most recently published Platinum Publications.
The Scientific Library maintains the NCI at Frederick-in-Print database, a collection of citations for journal articles authored by NCI at Frederick employees since 1997.
denotes Platinum Highlight article. Click on the image to go to the Platinum Highlight article.
BMC GENOMICS
Smircich P, Eastman G, Bispo S, Duhagon MA, Guerra-Slompo EP, Garat B, Goldenberg S, Munroe DJ, Dallagiovanna B, Holetz F, Sotelo-Silveira JR. Ribosome profiling reveals translation control as a key mechanism generating differential gene expression in Trypanosoma cruzi. BMC Genomics 16(1):443, 2015.
CANCER RESEARCH
Ridnour LA, Cheng RY, Weiss JM, Soto-Pantoja DR, Basudhar D, Heinecke JL, Stewart A, DeGraff WG, Sowers A, Thetford A, Kesarwala AH, Roberts DD, Young HA, Mitchell JB, Trinchieri G, Wiltrout RH, Wink DA. Nitric Oxide Synthase Inhibition Modulates Immune Polarization and Improves Radiation-Induced Tumor Growth Delay. Cancer Res 2015. [Epub ahead of print - This article is not yet available in the print journal.]
CARCINOGENESIS
Zhang LJ, Xiong Y, Nilubol N, He M, Bommareddi S, Zhu X, Jia L, Xiao Z, Park JW, Xu X, Patel D, Willingham MC, Cheng SY, Kebebew E. Testosterone regulates thyroid cancer progression by modifying tumor suppressor genes and tumor immunity. Carcinogenesis 36(4):420-8, 2015.
HUMAN MOLECULAR GENETICS
Ramsuran V, Kulkarni S, O'Huigin C, Yuki Y, Augusto DG, Gao X, Carrington M. Epigenetic regulation of differential HLA-A allelic expression levels. Hum Mol Genet 2015. [Epub ahead of print - This article is not yet available in the print journal.]
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
Holzinger D, Fassl SK, de Jager W, Lohse P, Rohrig UF, Gattorno M, Omenetti A, Chiesa S, Schena F, Austermann J, Vogl T, Kuhns DB, Holland SM, Rodriguez-Gallego C, Lopez-Almaraz R, Arostegui JI, Colino E, Roldan R, Fessatou S, Isidor B, Poignant S, Ito K, Epple HJ, Bernstein JA, Jeng M, Frankovich J, Lionetti G, Church JA, Ong PY, LaPlant M, Abinun M, Skinner R, Bigley V, Sachs UJ, Hinze C, Hoppenreijs E, Ehrchen J, Foell D, Chae JJ, Ombrello A, Aksentijevich I, Sunderkoetter C, Roth J. Single amino acid charge switch defines clinically distinct proline-serine-threonine phosphatase-interacting protein 1 (PSTPIP1)-associated inflammatory diseases. J Allergy Clin Immunol 2015. [Epub ahead of print - This article is not yet available in the print journal.]
JOURNAL OF BIOLOGICAL CHEMISTRY
Tykvart J, Barinka C, Svoboda M, Navratil V, Soucek R, Hubalek M, Hradilek M, Sacha P, Lubkowski J, Konvalinka J. Structural and Biochemical Characterization of a Novel Aminopeptidase from Human Intestine. J Biol Chem 290(18):11321-11336, 2015.
JOURNAL OF CELL BIOLOGY
Gerber PP, Cabrini M, Jancic C, Paoletti L, Banchio C, von Bilderling C, Sigaut L, Pietrasanta LI, Duette G, Freed EO, Saint Basile GD, Moita CF, Moita LF, Amigorena S, Benaroch P, Geffner J, Ostrowski M. Rab27a controls HIV-1 assembly by regulating plasma membrane levels of phosphatidylinositol 4,5-bisphosphate. J Cell Biol 209(3):435-452, 2015.
JOURNAL OF CLINICAL ONCOLOGY
Do K, Wilsker D, Ji J, Zlott J, Freshwater T, Kinders RJ, Collins J, Chen AP, Doroshow JH, Kummar S. Phase I Study of Single-Agent AZD1775 (MK-1775), a Wee1 Kinase Inhibitor, in Patients With Refractory Solid Tumors. J Clin Oncol 2015. [Epub ahead of print - This article is not yet available in the print journal.]
JOURNAL OF INFECTIOUS DISEASES
Kovacs SB, Sheikh V, Thompson WL, Morcock DR, Perez-Diez A, Yao MD, Rupert AW, Utay NS, Roby G, Freeman AF, Estes JD, Sereti I. T-cell depletion in the colonic mucosa of patients with idiopathic CD4 lymphopenia. J Infect Dis 2015. [Epub ahead of print - This article is not yet available in the print journal.]
JOURNAL OF MEDICINAL CHEMISTRY
Beck DE, Abdelmalak M, Lv W, Reddy PVN, Tender GS, O'Neill E, Agama K, Marchand C, Pommier Y, Cushman M. Discovery of Potent Indenoisoquinoline Topoisomerase I Poisons Lacking the 3-Nitro Toxicophore. J Med Chem 58(9):3997-4015, 2015.
Pescatori L, Metifiot M, Chung S, Masoaka T, Cuzzucoli Crucitti G, Messore A, Pupo G, Madia VN, Saccoliti F, Scipione L, Tortorella S, Di Leva FS, Cosconati S, Marinelli L, Novellino E, Le Grice SF, Pommier Y, Marchand C, Costi R, Di Santo R. N-Substituted Quinolinonyl Diketo Acid Derivatives as HIV Integrase Strand Transfer Inhibitors and Their Activity against RNase H Function of Reverse Transcriptase. J Med Chem 2015. [Epub ahead of print - This article is not yet available in the print journal.]
JOURNAL OF VIROLOGY
Chowdhury A, Hayes TL, Bosinger SE, Lawson BO, Vanderford T, Schmitz JE, Paiardini M, Betts M, Chahroudi A, Estes JD, Silvestri G. Differential impact of in vivo CD8+ T-lymphocyte depletion in controller versus progressor SIV-infected macaques. J Virol 2015. [Epub ahead of print - This article is not yet available in the print journal.]
Georgiev IS, Joyce MG, Yang YP, Sastry M, Zhang BS, Baxa U, Chen RTE, Druz A, Lees CR, Narpala S, Schon A, Van Galen J, Chuang GY, Gorman J, Harned A, Pancera M, Stewart-Jones GBE, Cheng C, Freire E, McDermott AB, Mascola JR, Kwong PD. Single-Chain Soluble BG505.SOSIP gp140 Trimers as Structural and Antigenic Mimics of Mature Closed HIV-1 Env. J Virol 89(10):5318-5329, 2015.
Hulot SL, Korber B, Giorgi EE, Vandergrift N, Saunders KO, Balachandran H, Mach LV, Lifton MA, Pantaleo G, Tartaglia J, Phogat S, Jacobs B, Kibler K, Perdiguero B, Gomez CE, Esteban M, Rosati M, Felber BK, Pavlakis GN, Parks R, Lloyd K, Sutherland L, Scearce R, Letvin NL, Seaman MS, Alam SM, Montefiori D, Liao HX, Haynes BF, Santra S. Comparison of Immunogenicity in Rhesus Macaques of Transmitted-Founder, HIV-1 Group M Consensus, and Trivalent Mosaic Envelope Vaccines Formulated as a DNA Prime, NYVAC, and Envelope Protein Boost. J Virol 89(12):6462-6480, 2015.
O’Connor GM, Vivian JP, Gostick E, Pymm P, Lafont BAP, Price DA, Rossjohn J, Brooks AG, McVicar DW. Peptide-Dependent Recognition of HLA-B*57:01 by KIR3DS1. J Virol 89(10):5213-5221, 2015.
Schafer JL, Li HY, Evans TI, Estes JD, Reeves RK. Accumulation of Cytotoxic CD16(+) NK Cells in Simian Immunodeficiency Virus-Infected Lymph Nodes Associated with In Situ Differentiation and Functional Anergy. J Virol 89(13):6887-6894, 2015.
Shen X, Duffy R, Howington R, Cope A, Sadagopal S, Park H, Pal R, Kwa S, Ding S, Yang OO, Fouda GG, Le Grand R, Bolton D, Esteban M, Phogat S, Roederer M, Amara R, Picker LJ, Seder RA, McElrath MJ, Barnett S, Permar SR, Shattock R, DeVico AL, Felber BK, Pavlakis GN, Pantaleo G, Korber BT, Montefiori DC, Tomaras GD. Vaccine Induced Epitope Specific Antibodies to SIVmac239 Envelope Are Distinct from Those Induced to the HIV-1 Envelope in Non-Human Primates. J Virol 2015. [Epub ahead of print - This article is not yet available in the print journal.]
LANCET
Kibuuka H, Berkowitz NM, Millard M, Enama ME, Tindikahwa A, Sekiziyivu AB, Costner P, Sitar S, Glover D, Hu ZH, Joshi G, Stanley D, Kunchai M, Eller LA, Bailer RT, Koup RA, Nabel GJ, Mascola JR, Sullivan NJ, Graham BS, Roederer M, Michael NL, Robb ML, Ledgerwood JE, Team RVS. Safety and immunogenicity of Ebola virus and Marburg virus glycoprotein DNA vaccines assessed separately and concomitantly in healthy Ugandan adults: a phase 1b, randomised, double-blind, placebo-controlled clinical trial. Lancet 385(9977):1545-1554, 2015.
MOLECULAR AND CELLULAR BIOLOGY
Meng L, Park JE, Kim TS, Lee EH, Park SY, Zhou M, Bang JK, Lee KS. Bimodal Interaction of Mammalian Polo-Like Kinase 1 and a Centrosomal Scaffold, Cep192, in the Regulation of Bipolar Spindle Formation. Mol Cell Biol 2015. [Epub ahead of print - This article is not yet available in the print journal.]
NATURE
Liu Y, Holmstrom E, Zhang J, Yu P, Wang J, Dyba MA, De C, Ying J, Lockett S, Nesbitt DJ, Ferre-D'Amare AR, Sousa R, Stagno JR, Wang YX. Synthesis and applications of RNAs with position-selective labelling and mosaic composition. Nature 2015. [Epub ahead of print - This article is not yet available in the print journal.]
NATURE IMMUNOLOGY
McLaren PJ, Carrington M. The impact of host genetic variation on infection with HIV-1. Nat Immunol 16(6):577-583, 2015.
NUCLEIC ACIDS RESEARCH
Levay A, Brenneman R, Hoinka J, Sant D, Cardone M, Trinchieri G, Przytycka TM, Berezhnoy A. Identifying high-affinity aptamer ligands with defined cross-reactivity using high-throughput guided systematic evolution of ligands by exponential enrichment. Nucleic Acids Res 2015. [Epub ahead of print - This article is not yet available in the print journal.]
PLOS COMPUTATIONAL BIOLOGY
Acuner Ozbabacan SE, Gursoy A, Nussinov R, Keskin O. The structural pathway of interleukin 1 (IL-1) initiated signaling reveals mechanisms of oncogenic mutations and SNPs in inflammation and cancer. PLoS Comput Biol 10(2):e1003470, 2014.
Lavender CA, Gorelick RJ, Weeks KM. Structure-Based Alignment and Consensus Secondary Structures for Three HIV-Related RNA Genomes. PLoS Comput Biol 11(5):e1004230, 2015.
Tsai CJ, Nussinov R. A unified view of "how allostery works". PLoS Comput Biol 10(2):e1003394, 2014.
PLOS ONE
Billioux A, Nakigozi G, Newell K, Chang LW, Quinn TC, Gray RH, Ndyanabo A, Galiwango R, Kiggundu V, Serwadda D, Reynolds SJ. Durable Suppression of HIV-1 after Virologic Monitoring-Based Antiretroviral Adherence Counseling in Rakai, Uganda. PLoS One 10(5):e0127235, 2015.
Kiris E, Nuss JE, Stanford SM, Wanner LM, Cazares L, Maestre MF, Du HT, Gomba GY, Burnett JC, Gussio R, Bottini N, Panchal RG, Kane CD, Tessarollo L, Bavari S. Phosphatase Inhibitors Function as Novel, Broad Spectrum Botulinum Neurotoxin Antagonists in Mouse and Human Embryonic Stem Cell-Derived Motor Neuron-Based Assays. PLoS One 10(6):e0129264, 2015.
Stewart-Jones GB, Thomas PV, Chen M, Druz A, Joyce MG, Kong WP, Sastry M, Soto C, Yang Y, Zhang B, Chen L, Chuang GY, Georgiev IS, McLellan JS, Srivatsan S, Zhou T, Baxa U, Mascola JR, Graham BS, Kwong PD. A Cysteine Zipper Stabilizes a Pre-Fusion F Glycoprotein Vaccine for Respiratory Syncytial Virus. PLoS One 10(6):e0128779, 2015.
Szabova L, Bupp S, Kamal M, Householder DB, Hernandez L, Schlomer JJ, Baran ML, Yi M, Stephens RM, Annunziata CM, Martin PL, Van Dyke TA, Weaver Ohler Z, Difilippantonio S. Pathway-specific engineered mouse allograft models functionally recapitulate human serous epithelial ovarian cancer. PLoS One 9(4):e95649, 2014.
Wandu WS, Tan C, Ogbeifun O, Vistica BP, Shi G, Hinshaw SJ, Xie C, Chen X, Klinman DM, Cai H, Gery I. Leucine-Rich Repeat Kinase 2 (Lrrk2) Deficiency Diminishes the Development of Experimental Autoimmune Uveitis (EAU) and the Adaptive Immune Response. PLoS One 10(6):e0128906, 2015.
Yang Z, Li J, Liu Q, Yuan T, Zhang Y, Chen LQ, Lou Q, Sun Z, Ying H, Xu J, Dimitrov DS, Zhang MY. Identification of Non-HIV Immunogens That Bind to Germline b12 Predecessors and Prime for Elicitation of Cross-clade Neutralizing HIV-1 Antibodies. PLoS One 10(5):e0126428, 2015.
PLOS PATHOGENS
Adland E, Paioni P, Thobakgale C, Laker L, Mori L, Muenchhoff M, Csala A, Clapson M, Flynn J, Novelli V, Hurst J, Naidoo V, Shapiro R, Huang KH, Frater J, Prendergast A, Prado JG, Ndung'u T, Walker BD, Carrington M, Jooste P, Goulder PJ. Discordant Impact of HLA on Viral Replicative Capacity and Disease Progression in Pediatric and Adult HIV Infection. PLoS Pathog 11(6):e1004954, 2015.
RETROVIROLOGY
Fennessey CM, Reid C, Lipkey L, Newman L, Oswald K, Piatak M, Jr., Roser JD, Chertova E, Smedley J, Gregory Alvord W, Del Prete GQ, Estes JD, Lifson JD, Keele BF. Generation and characterization of a SIVmac239 clone corrected at four suboptimal nucleotides. Retrovirology 1249, 2015.
Moulaei T, Alexandre KB, Shenoy SR, Meyerson JR, Krumpe LRH, Constantine B, Wilson J, Buckheit RW, McMahon JB, Subramaniam S, Wlodawer A, O'Keefe BR. Griffithsin tandemers: flexible and potent lectin inhibitors of the human immunodeficiency virus. Retrovirology 12(6):2015.
SCIENCE
Gres AT, Kirby KA, KewalRamani VN, Tanner JJ, Pornillos O, Sarafianos SG. X-ray crystal structures of native HIV-1 capsid protein reveal conformational variability. Science 349(6243):99-103, 2015.
VIROLOGY
Dunn LL, Boyer PL, Jane McWilliams M, Smith SJ, Hughes SH. Mutations in human immunodeficiency virus type 1 reverse transcriptase that make it sensitive to degradation by the viral protease in virions are selected against in patients. Virology 484:127-135, 2015.