Platinum Publications are selected from articles by NCI at Frederick scientists published in 42 prestigious science journals. This list represents articles published during the time period shown above, as generated from PubMed.
Articles designated as Platinum Highlights are noteworthy articles selected by Dr. Craig Reynolds, associate director, National Cancer Institute, from among the most recently published Platinum Publications.
The Scientific Library maintains the NCI at Frederick-in-Print database, a collection of citations for journal articles authored by NCI at Frederick employees since 1997.
denotes Platinum Highlight article. Click on the image to go to the Platinum Highlight article.
BIOPHYSICAL JOURNAL
Chavan TS, Jang H, Khavrutskii L, Abraham SJ, Banerjee A, Freed BC, Johannessen L, Tarasov SG, Gaponenko V, Nussinov R, Tarasova NI. High-affinity interaction of the K-Ras4B hypervariable region with the Ras active site. Biophys J 109(12):2602-13, 2015.
BLOOD
Dai L, Trillo-Tinoco J, Cao Y, Bonstaff K, Doyle L, Del Valle L, Whitby D, Parsons C, Reiss K, Zabaleta J, Qin Z. Targeting HGF/c-MET induces cell cycle arrest, DNA damage and apoptosis for primary effusion lymphoma. Blood 2015.
[Epub ahead of print - This article is not yet available in the print journal.]
Sheikh V, Porter BO, DerSimonian R, Kovacs SB, Thompson WL, Perez-Diez A, Freeman AF, Roby G, Mican J, Pau A, Rupert A, Adelsberger J, Higgins J, Bourgeois JS, Jr., Jensen SM, Morcock DR, Burbelo PD, Osnos L, Maric I, Natarajan V, Croughs T, Yao MD, Estes JD, Sereti I. Administration of interleukin-7 increases CD4 T cells in idiopathic CD4 lymphocytopenia. Blood 2015.
[Epub ahead of print - This article is not yet available in the print journal.]
CANCER RESEARCH
Nussinov R, Tsai CJ, Chakrabarti M, Jang H. A new view of Ras isoforms in cancers. Cancer Res 2015.
[Epub ahead of print - This article is not yet available in the print journal.]
JOURNAL OF BIOLOGICAL CHEMISTRY
Lu SY, Banerjee A, Jang H, Zhang J, Gaponenko V, Nussinov R. GTP binding and oncogenic mutations may attenuate hypervariable region (HVR)-catalytic domain interactions in small GTPase K-Ras4B, exposing the effector binding site. J Biol Chem 290(48):28887-28900, 2015.
JOURNAL OF CELL BIOLOGY
Hu Y. A feedforward loop of NLRC5 (de)ubiquitination keeps IKK–NF-kappaB in check. J Cell Biol 211(5):941-3, 2015.
JOURNAL OF CLINICAL INVESTIGATION
Micci L, Ryan ES, Fromentin R, Bosinger SE, Harper JL, He TY, Paganini S, Easley KA, Chahroudi A, Benne C, Gumber S, McGary CS, Rogers KA, Deleage C, Lucero C, Byrareddy SN, Apetrei C, Estes JD, Lifson JD, Piatak M, Chomont N, Villinger F, Silvestri G, Brenchley JM, Paiardini M. Interleukin-21 combined with ART reduces inflammation and viral reservoir in SIV-infected macaques. J Clin Invest 125(12):4497-4513, 2015.
JOURNAL OF IMMUNOLOGY
Jiang H, Promchan K, Lin BR, Lockett S, Chen, Marshall H, Badralmaa Y, Natarajan V. LZTFL1 upregulated by all-trans retinoic acid during CD4+ T cell activation enhances IL-5 production. J Immunol 2015.
[Epub ahead of print - This article is not yet available in the print journal.]
JOURNAL OF INFECTIOUS DISEASES
Matthews PC, Carlson JM, Beloukas A, Malik A, Jooste P, Ogwu A, Shapiro R, Riddell L, Chen F, Luzzi G, Jesuthasan G, Jeffery K, Jojic N, Ndung’u T, Carrington M, Goulder PJ, Geretti AM, Klenerman P. HLA-A is a predictor of hepatitis B e-antigen status in HIV-positive African adults. J Infect Dis 2015.
[Epub ahead of print - This article is not yet available in the print journal.]
Polizzotto MN, Millo C, Uldrick TS, Aleman K, Whatley M, Wyvill KM, O'Mahony D, Marshall V, Whitby D, Maass-Moreno R, Steinberg SM, Little RF, Yarchoan R. F-18-fluorodeoxyglucose positron emission tomography in Kaposi sarcoma herpesvirus-associated multicentric Castleman disease: correlation with activity, severity, inflammatory and virologic parameters. J Infect Dis 212(8):1250-1260, 2015.
JOURNAL OF MEDICINAL CHEMISTRY
Carta D, Bortolozzi R, Hamel E, Basso G, Moro S, Viola G, Ferlin MG. Novel 3-substituted 7-phenylpyrrolo 3,2-f quinolin-9(6H)-ones as single entities with multitarget antiproliferative activity. J Med Chem 58(20):7991-8010, 2015.
Medellin DC, Zhou Q, Scott R, Hill RM, Frail SK, Dasari R, Ontiveros SJ, Pelly SC, van Otterlo WA, Betancourt T, Shuster CB, Hamel E, Bai R, LaBarbera DV, Rogelj S, Frolova LV, Kornienko A. Novel microtubule-targeting 7-deazahypoxanthines derived from marine alkaloid rigidins with potent in vitro and in vivo anticancer activities. J Med Chem 2015.
[Epub ahead of print - This article is not yet available in the print journal.]
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Qin T, Iwata T, Ransom TT, Beutler JA, Porco JA, Jr. Syntheses of dimeric tetrahydroxanthones with varied linkages: investigation of “shapeshifting” properties. J Am Chem Soc 137(48):15225-33, 2015.
JOURNAL OF THE NATIONAL CANCER INSTITUTE
Lih CJ, Chen AP. Title: N of 2 responders with LMNA-NTRK1. J Natl Cancer Inst 2015.
[Epub ahead of print - This article is not yet available in the print journal.]
JOURNAL OF VIROLOGY
Bolton DL, Pegu A, Wang K, McGinnis K, Nason M, Foulds K, Letukas V, Schmidt SD, Chen X, Todd JP, Lifson J, Rao S, Michael NL, Robb ML, Mascola JR, Koup RA. HIV-1 monoclonal antibodies suppress acute SHIV viremia and limit seeding of cell-associated viral reservoirs. J Virol 2015.
[Epub ahead of print - This article is not yet available in the print journal.]
Cavallari I, Rende F, Bona MK, Sztuba-Solinska J, Silic-Benussi M, Tognon M, LeGrice SF, Franchini G, D'Agostino DM, Ciminale V. Expression of alternatively spliced HTLV-1 mRNAs is influenced by mitosis and by a novel cis-acting regulatory sequence. J Virol 2015.
[Epub ahead of print - This article is not yet available in the print journal.]
Datta SA, Clark PK, Fan L, Ma B, Harvin DP, Sowder RC, 2nd, Nussinov R, Wang YX, Rein A. Dimerization of the SP-1 region of HIV-1 Gag induces a helical conformation and association into helical bundles: implications for particle assembly. J Virol 2015.
[Epub ahead of print - This article is not yet available in the print journal.]
Fontana J, Keller P, Urano E, Ablan SD, Steven AC, Freed EO. Identification of an HIV-1 mutation in spacer peptide 1 that stabilizes the immature CA-SP1 lattice. J Virol 2015.
[Epub ahead of print - This article is not yet available in the print journal.]
Kearney MF, Wiegand A, Shao W, Coffin JM, Mellors JW, Lederman M, Gandhi RT, Keele BF, Li JZ. Origin of rebound plasma HIV includes cells with identical proviruses that are transcriptionally active before stopping antiretroviral therapy. J Virol 2015.
[Epub ahead of print - This article is not yet available in the print journal.]
Kinloch NN, MacMillan DR, Le AQ, Cotton LA, Bangsberg DR, Buchbinder S, Carrington M, Fuchs J, Harrigan PR, Koblin B, Kushel M, Markowitz M, Mayer K, Milloy MJ, Schechter MT, Wagner T, Walker BD, Carlson JM, Poon AF, Brumme ZL. Population-level immune-mediated adaptation in HIV-1 polymerase during the North American epidemic. J Virol 2015.
[Epub ahead of print - This article is not yet available in the print journal.]
Martins AN, Waheed AA, Ablan SD, Huang W, Newton A, Petropoulos CJ, Brindeiro RM, Freed EO. Elucidation of the molecular mechanism driving duplication of the HIV-1 PTAP late domain. J Virol 2015.
[Epub ahead of print - This article is not yet available in the print journal.]
Martins MA, Tully DC, Cruz MA, Power KA, de Santana MGV, Bean DJ, Ogilvie CB, Gadgil R, Lima NS, Magnani DM, Ejima K, Allison DB, Piatak M, Altman JD, Parks CL, Rakasz EG, Capuano S, Galler R, Bonaldo MC, Lifson JD, Allen TM, Watkins DI. Vaccine-induced simian immunodeficiency virus-specific CD8(+) T-cell responses focused on a single Nef spitope select for escape variants shortly after infection. J Virol 89(21):10802-10820, 2015.
Ranasinghe S, Soghoian DZ, Lindqvist M, Ghebremichael M, Donaghey F, Carrington M, Seaman MS, Kaufmann DE, Walker BD, Porichis F. HIV-1 antibody neutralization breadth is associated with enhanced HIV-specific CD4+ T cell responses. J Virol 2015.
[Epub ahead of print - This article is not yet available in the print journal.]
Wu JJ, Avey D, Li W, Gillen J, Fu B, Miley W, Whitby D, Zhu F. ORF33 and ORF38 of Kaposi's sarcoma-associated herpesvirus interact and are required for optimal production of infectious progeny viruses. J Virol 2015.
[Epub ahead of print - This article is not yet available in the print journal.]
MOLECULAR AND CELLULAR BIOLOGY
Huggins CJ, Mayekar MK, Martin N, Saylor KL, Gonit M, Jailwala P, Kasoji M, Haines DC, Quinones OA, Johnson PF. C/EBPgamma is a critical regulator of cellular stress response networks through heterodimerization with ATF4. Mol Cell Biol 2015.
[Epub ahead of print - This article is not yet available in the print journal.]
NATURE IMMUNOLOGY
Zhao E, Maj T, Kryczek I, Li W, Wu K, Zhao L, Wei S, Crespo J, Wan S, Vatan L, Szeliga W, Shao I, Wang Y, Liu Y, Varambally S, Chinnaiyan AM, Welling TH, Marquez V, Kotarski J, Wang H, Wang Z, Zhang Y, Liu R, Wang G, Zou W. Cancer mediates effector T cell dysfunction by targeting microRNAs and EZH2 via glycolysis restriction. Nat Immunol 2015.
[Epub ahead of print - This article is not yet available in the print journal.]
NUCLEIC ACIDS RESEARCH
Ajiro M, Jia R, Yang Y, Zhu J, Zheng ZM. A genome landscape of SRSF3-regulated splicing events and gene expression in human osteosarcoma U2OS cells. Nucleic Acids Res 2015.
[Epub ahead of print - This article is not yet available in the print journal.]
ONCOGENE
Xi S, Inchauste S, Guo H, Shan J, Xiao Z, Xu H, Miettenen M, Zhang MR, Hong JA, Raiji MT, Altorki NK, Casson AG, Beer DG, Robles AI, Bowman ED, Harris CC, Steinberg SM, Schrump DS. Cigarette smoke mediates epigenetic repression of miR-217 during esophageal adenocarcinogenesis. Oncogene 34(44):5548-5559, 2015.
PLOS GENETICS
Liu Y, Singh SR, Zeng X, Zhao J, Hou SX. The nuclear matrix protein Megator regulates stem cell asymmetric division through the mitotic checkpoint complex in Drosophila testes. PLoS Genet 11(12):e1005750, 2015.
PLOS PATHOGENS
Choi HS, Jain V, Krueger B, Marshall V, Kim CH, Shisler JL, Whitby D, Renne R. Kaposi’s sarcoma-associated herpesvirus (KSHV) induces the oncogenic miR-17-92 cluster and down-regulates TGF-beta signaling. PLoS Pathog 11(11):e1005255, 2015.
Drummond RA, Collar AL, Swamydas M, Rodriguez CA, Lim JK, Mendez LM, Fink DL, Hsu AP, Zhai B, Karauzum H, Mikelis CM, Rose SR, Ferre EM, Yockey L, Lemberg K, Kuehn HS, Rosenzweig SD, Lin X, Chittiboina P, Datta SK, Belhorn TH, Weimer ET, Hernandez ML, Hohl TM, Kuhns DB, Lionakis MS. CARD9-dependent neutrophil recruitment protects against fungal invasion of the central nervous system. PLoS Pathog 11(12):e1005293, 2015.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES
Chen J, Rahman SA, Nikolaitchik OA, Grunwald D, Sardo L, Burdick RC, Plisov S, Liang E, Tai S, Pathak VK, Hu WS. HIV-1 RNA genome dimerizes on the plasma membrane in the presence of Gag protein. Proc Natl Acad Sci U S A 2015.
[Epub ahead of print - This article is not yet available in the print journal.]
McLaren PJ, Coulonges C, Bartha I, Lenz TL, Deutsch AJ, Bashirova A, Buchbinder S, Carrington MN, Cossarizza A, Dalmau J, De Luca A, Goedert JJ, Gurdasani D, Haas DW, Herbeck JT, Johnson EO, Kirk GD, Lambotte O, Luo M, Mallal S, van Manen D, Martinez-Picado J, Meyer L, Miro JM, Mullins JI, Obel N, Poli G, Sandhu MS, Schuitemaker H, Shea PR, Theodorou I, Walker BD, Weintrob AC, Winkler CA, Wolinsky SM, Raychaudhuri S, Goldstein DB, Telenti A, de Bakker PI, Zagury JF, Fellay J. Polymorphisms of large effect explain the majority of the host genetic contribution to variation of HIV-1 virus load. Proc Natl Acad Sci U S A 112(47):14658-63, 2015.
Tedbury PR, Novikova M, Ablan SD, Freed EO. Biochemical evidence of a role for matrix trimerization in HIV-1 envelope glycoprotein incorporation. Proc Natl Acad Sci U S A 2015.
[Epub ahead of print - This article is not yet available in the print journal.]
Vitre B, Holland AJ, Kulukian A, Shoshani O, Hirai M, Wang Y, Maldonado M, Cho T, Boubaker J, Swing DA, Tessarollo L, Evans SM, Fuchs E, Cleveland DW. Chronic centrosome amplification without tumorigenesis. Proc Natl Acad Sci U S A 112(46):E6321-30, 2015.
RETROVIROLOGY
Kearney MF, Anderson EM, Coomer C, Smith L, Shao W, Johnson N, Kline C, Spindler J, Mellors JW, Coffin JM, Ambrose Z. Well-mixed plasma and tissue viral populations in RT-SHIV-infected macaques implies a lack of viral replication in the tissues during antiretroviral therapy. Retrovirology 1293, 2015.
VIROLOGY
Majerciak V, Zheng ZM. Alternative RNA splicing of KSHV ORF57 produces two different RNA isoforms. Virology 48881-87, 2015.