Thursday, November 14, 2019

09:00 am - 09:15 am EST
Welcome and Introductions

Mirit Aladjem, Ph.D.
Center for Cancer Research, NCI

Session 1:  Chromatin Organization and Dynamics
Chair:  Gordon Hager, Ph.D. CCR, NCI
Munira Basrai, Ph.D., CCR, NCI

09:15 am - 09:45 am EST
Epigenetic Genome Control by Heterochromatin Machinery

Shiv Grewal, Ph.D.
Center for Cancer Research, NCI

09:45 am - 10:15 am EST
Painting Chromatin with Synthetic Protein Chemistry

Thomas Muir, Ph.D.
Princeton University

10:15 am - 10:45 am EST
Shaping of the 3D Genome by Retrotransposons

Bing Ren, Ph.D.
University of California San Diego

10:45 am - 11:15 am EST
11:15 am - 11:45 am EST
Can Phase-Separation Explain the Biological Behaviors of Heterochromatin

Geeta Narlikar, Ph.D.
University of California, San Francisco

11:45 am - 12:15 pm EST
Super-Resolution Imaging of Transcription in Live Mammalian Cells

Ibrahim Cisse, Ph.D.
Massachusetts Institute of Technology

12:15 pm - 02:00 pm EST

Session 2:  Chromatin Reprogramming During Development
                    Chair:  Ashish Lal, Ph.D., CCR, NCI
David Clark, Ph.D., NICHD, NIH

02:00 pm - 02:30 pm EST
Principles of Epigenetics and Chromatin in Development and Human Disease

Ali Shilatifard, Ph.D.
Northwestern University

02:30 pm - 03:00 pm EST
Reprogramming of Promoter-Enhancer Contacts During Development

Rafael Casellas, Ph.D.
National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH

03:00 pm - 03:30 pm EST
3D Epigenome Reconfiguration in Brain Development and Disease

Jennifer Phillips-Cremins, Ph.D.
University of Pennsylvania

03:30 pm - 04:00 pm EST
04:00 pm - 04:30 pm EST
Overcoming Chromatin Barriers to Cell Fate Changes

Kenneth Zaret, Ph.D.
University of Pennsylvania

04:30 pm - 05:00 pm EST
Single-Cell Epigenomics During T Cell Differentiation

Keji Zhao, Ph.D.
National Heart, Lung and Blood Institute, NIH

05:00 pm - 05:30 pm EST
Dissecting Mechanisms that Safeguard Cell Identity

Konrad Hochedlinger, Ph.D.
Howard Hughes Medical Institute

Friday, November 15, 2019

Session 3:  Chromatin in Cancer & Aging
                    Chair:  Thomas Ried, M.D., CCR, NCI
Andre Nussenzweig, Ph.D., CCR, NCI

09:00 am - 09:30 am EST
Epigenetics and Functional Intratumor Heterogeneity

Paola Scaffidi, Ph.D.
The Francis Crick Institute

09:30 am - 10:00 am EST
Changing Cancer Cell Initiation and Fate Through Transcriptional Control

Leonard Zon, Ph.D.
Harvard Medical School

10:00 am - 10:30 am EST
Cracking Nuclear Codes: Finding Order in Chaos

Clodagh O’Shea, Ph.D.
Salk Institute for Biological Studies

10:30 am - 11:00 am EST
11:00 am - 11:30 am EST
Abnormal, Promoter DNA Hypermethylation – A Key Determinant of Cancer Stem Cell States and Age-Related Cancer Initiation Risk

Stephen Baylin, M.D.
Johns Hopkins School of Medicine

11:30 am - 12:00 pm EST
Assembly and Functions of DNA Repair Domains

Jean Gautier, Ph.D.
Columbia University

12:00 pm - 12:30 pm EST
In the Mood for Chaperones and Histone Variants, a LifeTime Operation

Genevieve Almouzni, Ph.D.
Institut Curie

12:30 pm - 02:00 pm EST

Session 4:  Chromatin, Disease and Therapeutics
                    Chair:  Shalini Oberdoerffer, Ph.D., CCR, NCI
                                Michael Bustin, Ph.D., CCR, NCI

02:00 pm - 02:30 pm EST
Landscape of Mouse Meiotic DNA END Processing

Andre Nussenzweig, Ph.D.
Center for Cancer Research, NCI


02:30 pm - 03:00 pm EST
Unraveling Lineage Specific Transcription Factors that Drive Self-Renewal and Differentiation in Neuroblastoma

Carol Thiele, Ph.D.
Center for Cancer Research, NCI

03:00 pm - 03:30 pm EST
Epigenetic Lesions and Chromosomal Topology in Cancer

Bradley Bernstein, MD, Ph.D.
Harvard University

03:30 pm - 04:00 pm EST
Epigenetic Resistance to Targeted Therapy in Lymphoma

Lou Staudt, M.D., Ph.D.
Center for Cancer Research, NCI